- Fluoxetine Protects against Big Endothelin-1 Induced Anti-Apoptosis by Rescuing Kv1.5 Channels in Human Pulmonary Arterial Smooth Muscle Cells
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Dai F, Mao Z, Xia J, Zhu S, Wu Z
- KMID: 1716887
- Yonsei Med J.
- 2012 Jul;53(4):842-848.
- doi: 10.3349/ymj.2012.53.4.842
PURPOSE: Pulmonary Kv channels are thought to play a crucial role in the regulation of cell proliferation and apoptosis. Previous studies have shown that fluoxetine upregulated the expression of Kv1.5... -
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- Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells
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Yun BR, Lee MJ, Kim JH, Kim IH, Yu GR, Kim DG
- KMID: 994402
- Exp Mol Med.
- 2010 Nov;42(11):787-797.
- doi: 10.3858/emm.2010.42.11.082
Cholangiocarcinoma (CC) is a chemoresistant intrahepatic bile duct carcinoma with a poor prognosis. The aims of this study were to identify molecular pathways that enhance sesquiterpene lactone parthenolide (PTL)-induced anticancer... -
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- Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells
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Jang JY, Kim MK, Jeon YK, Joung YK, Park KD, Kim CW
- KMID: 1365902
- Exp Mol Med.
- 2012 Apr;44(4):251-259.
- doi: 10.3858/emm.2012.44.4.019
Cancer stem cells (CSCs) are resistant to chemo- and radio-therapy, and can survive to regenerate new tumors. This is an important reason why various anti-cancer therapies often fail to completely... -
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