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Effects of Na+, K(+)-pump inhibitors on acetylcholine-induced relaxation in the rabbit aorta

Lee YH, Ahn DS, Song HJ, Kim YH, Kim HS, Ahn SH, Kang BS

The purpose of this study was to investigate the effects of inhibitors of the Na+, K(+)-pump and membrane depolarizing agents on endothelium-dependent acetylcholine-induced relaxation in the rabbit thoracic aorta. Aortic...
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Effect of Panax Ginseng Alcohol Extract on Cardiovascular System

Hah JS, Kang BS, Kang DH

The effects of the alcohol extract of Panax ginseng on the myocardial contractility particularly with respect to Bowditch and Woodworth phenomena and the norepinephrine induced contraction of the vascular smooth...
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Chronological effects of atherogenic diets on the aorta, liver and spleen of rabbits

Song SH, Min BI, Lee JH, Cho KS

To investigate the temporal progression of atherogenesis on the aorta and involvement of the monocyte-macrophage system in the liver and spleen, we fed 74 rabbits with high fat (14 or...
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Effects of vanadate on vascular contractility and membrane potential in the rabbit aorta

Chung SM, Ahn DS, Seok HS, Jeong Y, Kang BS

Isolated rabbit aortic ring with intact endothelial cell preparations precontracted with NE (10(-7) M) were relaxed by vanadate in a dose dependent manner (from 0.2 to 2 mM). Application of...
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The effect of anti-hypertensive drugs on DNA synthesis and proliferation of ultured rat aortic smooth muscle cells

Kang SW, Lee IH, Choi KH, Lee HY, Han DS

The aim of this study was to elucidate the effects of anti-hypertensive drugs, nifedipine, furosemide, hydrochlorothiazide, captopril, and atenolol on DNA synthesis and proliferation of cultured rat aortic...
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Cinnamyl alcohol attenuates vasoconstriction by activation of K+ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase

Kang YH, Yang IJ, Morgan KG, Shin HM

  • KMID: 1402319
  • Exp Mol Med.
  • 2012 Dec;44(12):749-755.
Cinnamyl alcohol (CAL) is known as an antipyretic, and a recent study showed its vasodilatory activity without explaining the mechanism. Here we demonstrate the vasodilatory effect and the mechanism of...
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Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity

Woo A, Min B, Ryoo S

Arginase competitively inhibits nitric oxide synthase (NOS) via use of the common substrate L-arginine. Arginase II has recently reported as a novel therapeutic target for the treatment of cardiovascular diseases...
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Inhibitory effect of Hsp70 on angiotensin II-induced vascular smooth muscle cell hypertrophy

Zheng Y, Im CN, Seo JS

  • KMID: 1098085
  • Exp Mol Med.
  • 2006 Oct;38(5):509-518.
Angiotensin II (Ang II), which is an important mediator of both vascular responsiveness and growth, has been shown to induce vascular smooth muscle cell (VSMC) hypertrophy via the activation of...
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Attenuated release of atrial natriuretic peptide and vasorelaxation in streptozotocin-induced diabetic rats

Choi KC, Park HC, Lee J

The present study was aimed at investigating the atrial natriuretic peptide (ANP) and urinary responses to acute perturbations in fluid balance and the vascular function in diabetes mellitus (DM). DM...
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