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Morin Hydrate Inhibits Influenza Virus entry into Host Cells and Has Anti-inflammatory Effect in Influenzainfected Mice

Hong EH, Song aH, Kim SR, Cho J, Jeong B, Yang H, Jeong JH, Ahn JH, Jeong H, Kim SE, Chang SY, Ko HJ

Influenza virus is the major cause of seasonal and pandemic flu. Currently, oseltamivir, a potent and selective inhibitor of neuraminidase of influenza A and B viruses, is the drug of...
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Unmet needs of chronic hepatitis C in the era of direct-acting antiviral therapy

Huang CF, Yu ML

The treatment of chronic hepatitis C (CHC) has been revolutionized in an era of all-oral direct-acting antivirals (DAAs) since 2014. Satisfactory treatment efficacy and tolerability can be provided by novel...
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Discussion on critical points for a tailored therapy to cure hepatitis C virus infection

Marascio N, Quirino A, Barreca GS, Galati L, Costa C, Pisani V, Mazzitelli M, Matera G, Liberto MC, Focà A, Torti C

Hepatitis C virus (HCV) infects around 71 million people worldwide and in 2018 it is still a major health problem. Since 2011, anti-HCV therapy with availability of direct-acting antiviral drugs...
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Upcoming direct acting antivirals for hepatitis C patients with a prior treatment failure

Parigi TL, Torres MC, Aghemo A

Despite the high efficacy of direct acting antivirals (DAAs) not all patients successfully clear hepatitis C virus infection, in fact, approximately 1–3% fail to reach a sustained virological response 12...
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2017 KASL clinical practice guidelines management of hepatitis C: Treatment of chronic hepatitis C

The Korean Association for the Study of the Liver (KASL)

No abstract available.
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Evolution of glomerular filtration rates and neutrophil gelatinase-associated lipocalin during treatment with direct acting antivirals

Strazzulla A, Coppolino , Barreca GS, Gentile I, Rivoli L, Postorino , Mazzitelli M, Greco G, Costa C, Pisani V, Marascio N, Simeoni M, Focà A, Fuiano G, Foti D, Gulletta E, Torti C

BACKGROUND/AIMS: Correct renal function evaluation is based on estimated glomerular filtration rates (eGFR) and complementary renal damage biomarkers, such as neutrophil gelatinase associated lipocalin (NGAL). The aim of this study...
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Management of hepatitis C viral infection in chronic kidney disease patients on hemodialysis in the era of direct-acting antivirals

Ko SY, Choe WH

The advent of novel, direct-acting antiviral (DAA) regimens for hepatitis C virus (HCV) infection has revolutionized its treatment by producing a sustained virologic response of more than 95% with few...
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Barriers to treatment of failed or interferon ineligible patients in the era of DAA: single center study

Seo KI, Yun BC, Li WJ, Lee SU, Han BH, Park ET

BACKGROUND/AIMS: Interferon-based treatment is not appropriate for a large number of patients with chronic hepatitis C for various medical and social reasons. Newly developed directly acting antivirals (DAAs) have been...
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The assessment of hepatocellular carcinoma risk in patients with chronic hepatitis B under antiviral therapy

Varbobitis I, Papatheodoridis GV

Hepatocellular carcinoma (HCC) is a primary concern for patients with chronic hepatitis B (CHB). Antiviral therapy has been reasonably the focus of interest for HCC prevention, with most studies reporting...
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Efficacy and safety of daclatasvir and asunaprevir for hepatitis C virus genotype 1b infection

Nam HC, Lee HL, Yang H, Song MJ

BACKGROUND/AIMS: The treatment strategy for hepatitis C virus (HCV) has been changing rapidly since the introduction of direct-acting antivirals such as daclatasvir (DCV) and asunaprevir (ASV). We evaluated the efficacy...
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Hepatitis C Viral Infection in Children: Updated Review

El-Guindi

Hepatitis C virus (HCV) infection is a major medical challenge affecting around 200 million people worldwide. The main site of HCV replication is the hepatocytes of the liver. HCV is...
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Management of direct antiviral agent failures

Buti M, Esteban R

The current standard of care for patients with chronic hepatitis C virus (HCV) infection is a combination of direct-acting antiviral agents (DAAs). Most HCV patients treated with these drugs achieve...
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Treatment of Chronic Hepatitis C Using Newly Developed Oral Antiviral Agents

Lee HW, Jung KS, Ahn SH

Standard care for chronic hepatitis C has been a combination of pegylated interferon-alpha and ribavirin, although this treatment has suboptimal antiviral efficacy and significant adverse events. The hepatitis C virus...
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Comparison of Guidelines for Management of Chronic Hepatitis C

Kim KA

Therapeutic options for patients with hepatitis C virus infection have evolved substantially with the advent of highly effective direct-acting antiviral agents (DAA). Guidelines for treatment of hepatitis C have changed...
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Chronic hepatitis B in pregnancy: unique challenges and opportunities

Yogeswaran K, Fung SK

Chronic hepatitis B (CHB) affects 350 million individuals worldwide. Perinatal transmission leads to high rates of chronic infection and complications, including cirrhosis and hepatocellular carcinoma. It is important to recognize...
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Strategy for Novel Vaccine and Antivirals Against Foot-and-Mouth Disease

Park JH, Kim SM, Lee KN, Ko YJ, Lee HS, Cho IS

Foot-and-mouth disease (FMD) is a highly contagious, virally induced disease of cloven-hoofed animals. FMD-affected countries have suffered from a serious economic impact due to their decreased participation in the international...
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A Case of Ganciclovir-resistant CMV Antigenemia by UL97 Phosphotransferase Mutant Strain after Cord Blood Transplantation

Park YS, Jeon YS, Cho B, Chung NG, Lee DG, Choi SM, Shin WS, Kim HK

  • KMID: 2278324
  • Korean J Pediatr Hematol Oncol.
  • 2004 Oct;11(2):265-270.
Despite the availability of effective antiviral drugs, human cytomegalovirus (CMV) infection is still a serious life-threatening complication in recipients of allogeneic hematopoietic stem cell transplantation. Ganciclovir (GCV) preemptive therapy is...
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