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Pharmacotherapy for late-life depression

Han KM

Background: Late-life depression (LLD) is one of the most common psychiatric disorders. However, LLD is often undetected or inadequately treated by clinicians. This review summarizes the recent research on pharmacotherapy...
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Long-term Safety and Efficacy of Esketamine Nasal Spray Plus an Oral Antidepressant in Patients with Treatment-resistant Depression– an Asian Sub-group Analysis from the SUSTAIN-2 Study

Jeon HJ, Ju PC, Sulaiman AH, Aziz SA, Paik JW, Tan W, Bai D, Li CT

Objective: To evaluate the long-term safety and efficacy of intranasal esketamine in patients with treatment-resistant depression from the Asian subgroup of the SUSTAIN-2 study. Methods: SUSTAIN-2 was a phase 3, open-label,...
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Improving Clinician-Patient Communication Alleviates Stigma in Patients With Functional Dyspepsia Receiving Antidepressant Treatment

Yan XJ, Qiu HY, Luo QQ, Wang B, Xu P, Ji CF, Chen SL

  • KMID: 2523788
  • J Neurogastroenterol Motil.
  • 2022 Jan;28(1):95-103.
  • doi: 10.5056/jnm20239
Background/Aims Antidepressants are effective in patients with functional dyspepsia (FD). However, stigma associated with FD and antidepressants may affect treatment adherence. This study aims to explore possible communication strategies to alleviate...
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Machine Learning and Deep Learning for the Pharmacogenomics of Antidepressant Treatments

Lin E, Lin CH, Lane HY

A growing body of evidence now proposes that machine learning and deep learning techniques can serve as a vital foundation for the pharmacogenomics of antidepressant treatments in patients with major...
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Depression in Primary Care

Shin J

Depression is a commonly encountered condition in the primary care that indicates low mood, loss of energy, sadness, loss of pleasure, sleep disorders or poor appetite, fatigue, and poor concentration....
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How to Utilize Clinical and Genetic Information for Personalized Treatment of Major Depressive Disorder: Step by Step Strategic Approach

Fabbri C, Serretti A

Depression is the single largest contributor to non-fatal health loss and affects 322 million people globally. The clinical heterogeneity of this disorder shows biological correlates and it makes the personalization...
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The Antidepressant Effects and Clinical Implication of Ketamine

Kim BS

  • KMID: 2503847
  • J Korean Soc Biol Ther Psychiatry.
  • 2020 Jun;26(2):79-87.
Major depressive disorder is a highly prevalent psychiatric condition that causes serious health concern and psychosocial consequences. Nevertheless, about one third of the patients with major depressive disorder have treatmentresistant...
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All about pain pharmacology: what pain physicians should know

Kim KH, Seo HJ, Abdi S, Huh B

From the perspective of the definition of pain, pain can be divided into emotional and sensory components, which originate from potential and actual tissue damage, respectively. The pharmacologic treatment of...
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Symptom-based selection of antidepressants

Park SC

Most evidence-based pharmacological guidelines recommend selective serotonin reuptake inhibitors, serotoninnorepinephrine reuptake inhibitors, norepinephrine-dopamine reuptake inhibitors or norepinephrine and specific serotonin antidepressants as the first-line treatment for major depression. Since the...
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Perioperative duloxetine as part of a multimodal analgesia regime reduces postoperative pain in lumbar canal stenosis surgery: a randomized, triple blind, and placebo-controlled trial

Govil N, Parag K, Arora P, Khandelwal H, Singh A, R

Background: Duloxetine is an antidepressant that is also useful in chronic neuropathic and central origin pain. In this study, the role of duloxetine in decreasing acute postoperative pain after lumbar...
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Antidepressants in Spine Surgery: A Systematic Review to Determine Benefits and Risks

Bayoumi AB, Ikizgul O, Karaali CN, Bozkurt S, Konya D, Toktas ZO

Antidepressant drugs can be advantageous in treating psychiatric and non-psychiatric illnesses, including spinal disorders. However, spine surgeons remain unfamiliar with the advantages and disadvantages of the use of antidepressant drugs...
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Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists

Park JY, Chae S, Kim CS, Kim YJ, Yi HJ, Han E, Joo Y, Hong S, Yun JW, Kim H, Shin KH

Nociceptin/orphanin FQ (N/OFQ) and its receptor, nociceptin opioid peptide (NOP) receptor, are localized in brain areas implicated in depression including the amygdala, bed nucleus of the stria terminalis, habenula, and...
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The Epidemiology of Antidepressant Prescriptions in South Korea from the Viewpoint of Medical Providers: A Nationwide Register-Based Study

Kim MJ, Kim N, Shin D, Rhee SJ, Park CH, Kim H, Yang B, Ahn YM

Antidepressants are widely used to treat depression in Korea, however, only a few studies have focused on the provider of the treatment. The aim of the study is to compare...
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Prescription Pattern of Antidepressants in Korea for Major Neurological Disorders: Before the Policy Change in 2017

Park Y, Baek ES, Choi J, Lee J, Lee SH, Park KW

BACKGROUND: It is well known that patients with neurological disorders are vulnerable to depression. However, in Korea, National Health Insurance services had banned non-psychiatrists from prescribing antidepressants for more than...
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Pharmacological Therapy in Panic Disorder: Current Guidelines and Novel Drugs Discovery for Treatment-resistant Patient

Zulfarina , Syarifah-Noratiqah SB, Nazrun SA, Sharif R, Naina-Mohamed I

Panic disorder (PD) being one of the most intensively investigated anxiety disorders is considered a heterogeneous psychiatric disease which has difficulties with early diagnosis. The disorder is recurrent and usually...
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Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Lee JO, Kim JW, Kang HJ, Hong JP, Kim JM

OBJECTIVE: Cognitive disturbance is one of the major symptoms of depression and may be improved by treatment with antidepressants. This study aimed to investigate the predictors of cognitive improvement in...
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Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review

Wang SM, Han C, Bahk WM, Lee SJ, Patkar AA, Masand PS, Pae CU

Randomized trials have shown that selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have better safety profiles than classical tricyclic antidepressants (TCAs). However, an increasing number of studies,...
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The Effect of Antidepressants on Mesenchymal Stem Cell Differentiation

Kruk JS, Bermeo S, Skarratt K, Fuller SJ, Duque G

BACKGROUND: Use of antidepressant medications has been linked to detrimental impacts on bone mineral density and osteoporosis; however, the cellular basis behind these observations remains poorly understood. The effect does...
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The Present and Future of Precision Medicine in Psychiatry: Focus on Clinical Psychopharmacology of Antidepressants

Serretti A

Precision medicine is a concept which is recently gaining momentum in all branches of medicine. In particular in psychiatry it is greatly needed given the huge societal costs of psychiatric...
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Prescription Pattern of Antidepressants for Children and Adolescents in Korea Based on Nationwide Data

Chon MW, Lee J, Chung S, Kim Y, Kim HW

Antidepressant prescription for youths has recently been on the increase. There is a growing concern over the increasing off-label usage of antidepressants. Current data on off-label antidepressant usage vary across...
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