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The Effect of Anoxia on the Amino Acid and Carbohydrate Metabolism of the Isolated Dog Brain

Huh K, Gilboe DD, Minsker DH

The isolated dog brain was perfused for a period of 4 minutes with blood normal in all constituents, but pathologically low in oxygen in order to follow the metabolic response...
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Hypoxic Regulation of VEGF, HIF-1 (alpha) in Coronary Collaterals Development

Sung KC, Kim KS, Lee S

BACKGROUND: The interindividual variability for the development of collaterals in coronary artery disease is dependent on the hypoxic induction level of VEGF. To determine whether the hypoxic induction of VEGF...
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Involvement of MAPK pathway in hypoxia-induced up-regulation of urokinase plasminogen activator receptor in a human prostatic cancer cell line, PC3MLN4

Lee KH, Choi EY, Hyun MS, Kim JR

  • KMID: 755666
  • Exp Mol Med.
  • 2004 Feb;36(1):57-64.
Clinical studies have shown that tumor hypoxia is associated with invasive growth and metastasis and may be an important prognostic factor adversely influencing survival in patients with tumors. To investigate...
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Hypoxia Delays the Intracellular Ca2+ Clearance by Na+ - Ca2+ Exchanger in Human Adult Cardiac Myocytes

Park SI, Park EJ, Kim NH, Baek WK, Lee YT, Lee CJ, Suh CK

Transient myocardial ischemia during cardiac surgery causes a loss of energy sources, contractile depression, and accumulation of metabolites and H+ ion resulting in intracellular acidosis. The reperfusion following ischemic cardioplegia...
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