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The treatment of Graves' disease in children and adolescents

Lee HS, Hwang JS

Graves' disease (GD) accounts for 10%-15% of thyroid disorders in children and adolescents. The use of antithyroid drugs as the initial treatment option in GD is well accepted. An average...
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A case of thyrotoxic periodic paralysis as initial manifestation of Graves' disease in a 16-year-old Korean adolescent

Jung SY, Song KC, Shin JI, Chae HW, Kim HS, Kwon AR

Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism, with recurrent muscle paralysis and hypokalemia that are caused by an intracellular shift of potassium. TPP is relatively common in...
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A 3-year-old girl with Graves' disease with literature review

Ho YH, Chung EC, Park SA

Graves' disease, the main cause of hyperthyroidism in the pediatric age group, is very rare in children younger than 4 years old but can seriously interfere with growth and development...
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Prepubertal unilateral gynecomastia in the absence of endocrine abnormalities

Kang M, Lee CJ, Hwang IT, Lee K, Kang MJ

Gynecomastia is defined as the excessive development of breast tissue in males, which can occur as unilateral or bilateral. Although the overall prevalence of gynecomastia is 40%-65%, the prepubertal unilateral...
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Neonatal screening and a new cause of congenital central hypothyroidism

Tajima T, Nakamura A, Morikawa S, Ishizu K

Congenital central hypothyroidism (C-CH) is a rare disease in which thyroid hormone deficiency is caused by insufficient thyrotropin (TSH) stimulation of a normally-located thyroid gland. Most patients with C-CH have...
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Earlier re-evaluation may be possible in pediatric patients with eutopic congenital hypothyroidism requiring lower L-thyroxine doses

Cho MS, Cho GS, Park SH, Jung MH, Suh BK, Koh DG

PURPOSE: The incidence of congenital hypothyroidism (CH) has increased in several countries. Lower cut-off in screening programs have led to an increase in the proportion of transient hypothyroidism (TH) cases...
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New Korean reference for birth weight by gestational age and sex: data from the Korean Statistical Information Service (2008-2012)

Lim JS, Lim SW, Ahn JH, Song BS, Shim KS, Hwang IT

PURPOSE: To construct new Korean reference curves for birth weight by sex and gestational age using contemporary Korean birth weight data and to compare them with the Lubchenco and the...
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No influence of parental origin of intact X chromosome and/or Y chromosome sequences on three-year height response to growth hormone therapy in Turner syndrome

Lee HJ, Jung HW, Lee GM, Kim HY, Kim JH, Lee SH, Kim JH, Lee YA, Shin CH, Yang SW

PURPOSE: Whether parental origin of the intact X chromosome and/or the presence of Y chromosome sequences (Yseq) play a role in three-year height response to growth hormone (GH) were investigated. METHODS:...
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Long-term follow-up on Cushing disease patient after transsphenoidal surgery

Jeong I, Oh M, Kim JH, Cho JH, Choi JH, Yoo HW

Cushing disease is caused by excessive adrenocorticotropic hormone (ACTH) production by the pituitary adenoma. Transsphenoidal surgery is its first-line treatment. The incidence of Cushing disease in children and adolescents is...
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Significant adverse reactions to long-acting gonadotropin-releasing hormone agonists for the treatment of central precocious puberty and early onset puberty

Lee JW, Kim HJ, Choe YM, Kang HS, Kim SK, Jun YH, Lee JE

PURPOSE: Long-acting gonadotropin-releasing hormone agonists (GnRHa) are commonly used to treat central precocious puberty (CPP) in Korea. Although rare, there have been reports on the characteristic of adverse reactions of...
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