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Angiostatin Works as Immune Modulatory Molecules via Inhibition of Neutrophil Activation and Migration

Woo SY

Angiostatin is derived from enzymatic degradation of plasminogen and it has endogenous anti-angiogenic properties. Although tumor cells, macrophages, platelets, and neutrophils generate high amount of angiostatin, its expression is increased...
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Inhibition Effect of Angiostatin and Endostatin on Human Angiogenesis

Jung SP, Lee MH

  • KMID: 2324917
  • J Korean Surg Soc.
  • 2001 Jan;60(1):1-7.
PURPOSE: Angiogenesis is a critical determinant of tumor growth and the development of metastasis. Angiostatin and endostatin have been used in a variety of in vitro and in vivo animal...
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The Role of Angiostatin, Vascular Endothelial Growth Factor, Matrix Metalloproteinase 9 and 12 in the Angiogenesis of Hepatocellular Carcinoma

Kim S, Park HS, Son HJ, Moon WS

  • KMID: 760532
  • Korean J Hepatol.
  • 2004 Mar;10(1):62-72.
BACKGROUND/AIMS: Tumor angiogenesis, a major requirement for tumor growth and metastasis, is regulated by pro- and anti-angiogenic factors. Hepatocellular carcinoma (HCC) has become a common malignant tumor worldwide. It...
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cDNA Cloning and Expression of Angiostatin, an Angiogenesis Inhibitor , from Human Liver Tissue mRNA

Park MJ, Hwang BG, Son YS, Yi DH, Lee SH, Hong SI

  • KMID: 2175135
  • J Korean Cancer Assoc.
  • 1999 Dec;31(6):1236-1245.
PURPOSE: Angiostatin, a 38 kDa internal fragment of plasminogen, is a potent inhibitor of angiogenesis. It blocks neovascularization and growth of primary and metastatic tumors in mice. To produce recombinant...
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Expression of Angiostatin Using DNA-Based Semliki Forest Virus Replicon

Choi YS, Lee JS, Choi YK, Shin KS, Kim HS, Kim CJ

  • KMID: 1101573
  • J Vet Sci.
  • 2002 Mar;3(1):41-45.
Angiogenesis is recognized as a critical factor in the growth of tumor cells and plays a key role in the tumor metastasis. Recent studies for antiangiogenic substances are getting popular....
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