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Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1

Fukuhara S, Sako K, Noda K, Nagao K, Miura K, Mochizuki

Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor tyrosine kinase. Ang1-Tie2 signal has been proposed to exhibit two opposite roles in the controlling blood vessels. One is vascular stabilization and...
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