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Melittin Ameliorates the Inflammation of Organs in an Amyotrophic Lateral Sclerosis Animal Model

Lee SH, Choi SM, Yang EJ

Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disorder characterized by a selective loss of motor neurons in the spinal cord, brainstem, and motor cortex, leading to weakness of...
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Korean version of Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised: A Pilot Study on the Reliability and Validity

Kim HY, Park KH, Koh SH, Lee SC, Nam YH, Kim J, Kim SH

  • KMID: 1527858
  • J Korean Neurol Assoc.
  • 2007 May;25(2):149-154.
BACKGROUND: The Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) is a quantitative measure of ALS-related physical deficit with established reliability and validity in prospective clinical research. This study aimed to...
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Availability of Neurophysiological Index in Amyotrophic Lateral Sclerosis: Application of Neurophysiological Index to Median Nerve /Abductor Digiti Minimi and Posterior Tibial Nerve/Abductor Hallucis

Kim HY, Koh SH, Park J, Kim J, Kim SH

  • KMID: 2185241
  • J Korean Neurol Assoc.
  • 2007 Feb;25(1):16-22.
BACKGROUND: Neurophysiological Index (NI) is derived from compound muscle action potentials, distal motor latency and F-wave frequency in the ulnar nerve/abductor digiti minimi. Recent studies suggested that NI could be...
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Immunohistochemical Study on the Distribution of Glycogen Synthase Kinase (GSK) 3beta in the Central Nervous System of SOD1G93A Transgenic Mice

Joo KM, Chung YH, Kim SS, Kim KY, Lee WB, Cha CI

  • KMID: 1521308
  • Korean J Phys Anthropol.
  • 2007 Dec;20(4):355-362.
In the present study, we investigated influences of glycogen synthase kinase (GSK) 3beta on the development and/or progression of amyotrophic lateral sclerosis (ALS). We used transgenic mice expressing a human...
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Selective Cytotoxic Mechanism of Homocysteine to Motor Neuronal Cells Expressing the Mutant Cu,Zn-superoxide Dismutase

Sung JJ, Kim HJ, Kim SM, Min JH, Hong YH, Park KS, Kim M, Lee SH, Ho WK, Lee KW

  • KMID: 1957679
  • J Korean Neurol Assoc.
  • 2006 Feb;24(1):66-75.
BACKGROUND: Mutations in Cu, Zn-superoxide dismutase (SOD1) cause about 20% of familial amyotrophic lateral sclerosis (FALS) cases. The mechanism of late-onset disease manifestation despite the innate mutation has no clear...
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Neuroprotective Effect of Estrogen on Motor Neuron Cells Expressing Wild Type or Mutant Cu/Zn Superoxide Dismutase

Kim HJ, Park SH, Kim MH, Kim HJ, Lee KW

  • KMID: 2343020
  • J Korean Neurol Assoc.
  • 2002 Sep;20(5):525-529.
BACKGROUND: Recently, the mechanism involved in nitric oxide (NO)-mediated motor neuron death is under extensive investigation. The role of Cu/Zn superoxide dismutase (SOD) mutation, which is found in about 2%...
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Impairment of Neurite Formation in Familial ALS-associated Cu, Zn-Superoxide Dismutase Mutant Cells

Park KS, Kim HJ, Kim MH, Lee KW

  • KMID: 2137973
  • J Korean Neurol Assoc.
  • 2002 Nov;20(6):694-698.
BACKGROUND: Mutations in the human Cu, Zn-superoxide dismutase (SOD1) gene have been identified in some cases of familial amyotrophic lateral sclerosis (ALS). Neuronal cells with mutant SOD1 gene promoted cell...
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Visualization and Quantitative Analysis of Bulbar Palsy and Its Progression Using Sound Spectrography: A case report

Kim YC, Seo JH, Kim HG, Kim YH

  • KMID: 2323184
  • J Korean Acad Rehabil Med.
  • 1999 Feb;23(1):186-191.
Distortion of vowels in dysarthria associated with amyotrophic lateral sclerosis can be detected at the perceptual, physiological, and acoustical levels of analysis. Sound spectrography was used to analyse the formants...
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