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EF-hand like Region in the N-terminus of Anoctamin 1 Modulates Channel Activity by Ca²⁺ and Voltage

Tak MH, Jang Y, Son WS, Yang YD, Oh U

Anoctamin1 (ANO1) also known as TMEM16A is a transmembrane protein that functions as a Ca²⁺ activated chloride channel. Recently, the structure determination of a fungal Nectria haematococca TMEM16 (nhTMEM16) scramblase...
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Essential roles for ID-1 motif of interleukin-4 receptor alpha chain in interleukin-4 signaling

Youn J, Lee KH, Hwang WY, Paik DJ, Chung HS

  • KMID: 2285854
  • J Asthma Allergy Clin Immunol.
  • 2003 Jun;23(2):372-384.
BACKGROUND: Interleukin (IL)-4 is a pleiotropic cytokine that plays an important role in the pathogenesis of the allergic inflammation and asthma. Upon IL-4 receptor (IL-4R) engagement, a variety of signaling...
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