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Anesthetics and Glutamate Transporter

Do SH, Lim YJ

No abstract available.
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Glutamine Supplementation Ameliorates Chronic Stress-induced Reductions in Glutamate and Glutamine Transporters in the Mouse Prefrontal Cortex

Baek JH, Vignesh A, Son H, Lee DH, Roh GS, Kang SS, Cho GJ, Choi WS, Kim HJ

Chronic immobilization stress (CIS) induces low levels of glutamate (Glu) and glutamine (Gln) and hypoactive glutamatergic signaling in the mouse prefrontal cortex (PFC), which is closely related to the Glu-Gln...
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Effects of clonidine on the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes

Woo JH, Han JI, Baik HJ, Lee H

BACKGROUND: Clonidine has been shown to be a potent neuroprotectant by acting at alpha2 receptors on glutamatergic neurons to inhibit the release of glutamate. The aim of this study is...
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Remifentanil increases the activity of the glutamate transporter, EAAC1, expressed in Xenopus oocytes

Ryu J, Do SH, Lee N

  • KMID: 2046779
  • Anesth Pain Med.
  • 2008 Oct;3(4):264-269.
BACKGROUND: Remifentanil has gained wide clinical acceptance during anesthesia due to its short context-sensitive half time and organ-independent metabolism. However, its mechanism as an anesthetic remains unclear. Glutamate transporters may...
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Effect of propofol on oxidative stress-attenuated glutamate transporter EAAT4 activity

Ryu JH, Kim CS, Do SH, Park HS

  • KMID: 1741909
  • Anesth Pain Med.
  • 2011 Jul;6(3):225-230.
BACKGROUND: Propofol (2, 6-diisopropylphenol) has been known to have neuroprotective effects. Excitatory amino acid transporter 4 (EAAT4) is a glutamate transporter predominantly expressed in the cerebellar Purkinje cells, which is...
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A Patient Diagnosed with Spinocerebellar Ataxia Type 5 associated with SPTBN2: Case Report

Hur MW, Ko A, Lee HJ, Lee JS, Kang HC

Spinocerebellar ataxias (SCAs) are autosomal dominant neurodegenerative disorders which disrupt the afferent and efferent pathways of the cerebellum that cause cerebellar ataxia. Spectrin beta non-erythrocytic 2 (SPTBN2) gene encodes the...
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Polymorphism of the Glutamate Transporter Protein EAAT2 and Migraine Transformation into Chronic Daily Headache

Shin HE, Han SJ, Lee KS, Park JW

BACKGROUND AND PURPOSE: The progression of migraine into chronic daily headache involves multiple risk factors, but the main contributor is not known. Glutamate is the major excitatory neurotransmitter in central...
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Cloning and Localization of Developmentally Regulated Gene, Glutamate/Aspartate Transporter (GLAST) Gene, in the Developing Rat Cerebellum

Chang YJ, Shim JH, Kim C, Kim H, Rhyu IJ, Suh YS, Chun YH

  • KMID: 2224550
  • Korean J Anat.
  • 2000 Aug;33(4):381-391.
In this study, S59158, a gene of GLAST (L-Glutamate/L-Aspartate transporter), was cloned by ordered differential display PCR with developing rat brains. The mRNA expression of this gene in the developing...
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Alexander Disease

Kang JH, Hong SJ, Kim DK

Alexander disease (ALXD) is a rare demyelinating disease of the white matter of the brain that is caused by a mutation in the glial fibrillary acidic protein (GFAP) gene. The...
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Dietary Glutamate: Interactions With the Enteric Nervous System

Wang GD, Wang XY, Xia Y, Wood JD

  • KMID: 2381148
  • J Neurogastroenterol Motil.
  • 2014 Jan;20(1):41-53.
BACKGROUND/AIMS: Digestion of dietary protein elevates intraluminal concentrations of glutamate in the small intestine, some of which gain access to the enteric nervous system (ENS). Glutamate, in the central nervous...
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Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient

Woo J, Han YE, Koh W, Won J, Park MG, An H, Lee CJ

The neuronal activity-dependent change in the manner in which light is absorbed or scattered in brain tissue is called the intrinsic optical signal (IOS), and provides label-free, minimally invasive, and...
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In Silico Model-driven Assessment of the Effects of Brain-derived Neurotrophic Factor Deficiency on Glutamate and Gamma-Aminobutyric Acid: Implications for Understanding Schizophrenia Pathophysiology

Agrawal R, Kalmady SV, Venkatasubramanian G

OBJECTIVE: Deficient brain-derived neurotrophic factor (BDNF) is one of the important mechanisms underlying the neuroplasticity abnormalities in schizophrenia. Aberration in BDNF signaling pathways directly or circuitously influences neurotransmitters like glutamate...
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Blockade of Trigeminal Glutamate Recycling Produces Anti-allodynic Effects in Rats with Inflammatory and Neuropathic Pain

Yang KY, Lee MK, Park MK, Son JY, Ju JS, Ahn DK

The present study investigated the role of spinal glutamate recycling in the development of orofacial inflammatory pain or trigeminal neuropathic pain. Experiments were carried out on male Sprague-Dawley rats weighing...
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Altered Expression of Parvalbumin in Neural Retina of the Insulin-dependent Diabetic Rat

Park HS, Park SJ, Park SH, Chung JW, Chun MH, Oh SJ

  • KMID: 1937826
  • Korean J Anat.
  • 2006 Apr;39(2):149-158.
Calcium-binding proteins in the nervous system are functioned in Ca2+ buffering and Ca2+ transport and regulation of various enzyme systems. They potentially have a number of different effects on cells...
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