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Tooth-derived bone graft material

Kim YK, Lee J, Um IW, Kim KW, Murata M, Akazawa T, Mitsugi M

With successful extraction of growth factors and bone morphogenic proteins (BMPs) from mammalian teeth, many researchers have supported development of a bone substitute using tooth-derived substances. Some studies have also...
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Effects of Incentive Spirometry on Respiratory Motion in Healthy Subjects Using Cine Breathing Magnetic Resonance Imaging

Kotani T, Akazawa T, Sakuma T, Nagaya S, Sonoda M, Tanaka Y, Katogi T, Nemoto T, Minami S

OBJECTIVE: To investigate the effectiveness of incentive spirometry on respiratory motion in healthy subjects using cine breathing magnetic resonance imaging (MRI). METHODS: Ten non-smoking healthy subjects without any history of respiratory...
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Accuracy of Pedicle Screw Placement in Scoliosis Surgery: A Comparison between Conventional Computed Tomography-Based and O-Arm-Based Navigation Techniques

Kotani T, Akazawa T, Sakuma T, Koyama K, Nemoto T, Nawata K, Yamazaki A, Minami S

STUDY DESIGN: Retrospective study. PURPOSE: We compared the accuracy of O-arm-based navigation with computed tomography (CT)-based navigation in scoliotic surgery. OVERVIEW OF LITERATURE: No previous reports comparing the results of O-arm-based navigation...
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Improvements in Intractable Lumbar and LowerExtremity Symptoms after Systemic Administration of Tocilizumab, an Anti-interleukin-6 Receptor Antibody

Sainoh T, Sainoh T, Orita S, Orita S, Miyagi M, Miyagi M, Suzuki-Narita M, Suzuki-Narita M, Sakuma Y, Sakuma Y, Oikawa Y, Oikawa Y, Kubota G, Kubota G, Sato J, Sato J, Shiga Y, Shiga Y, Fujimoto K, Fujimoto K, Eguchi Y, Eguchi Y, Koda M, Koda M, Aoki Y, Aoki Y, Akazawa T, Akazawa T, Furuya T, Furuya T, Nakamura J, Nakamura J, Takahashi H, Takahashi H, Maki S, Maki S, Inoue M, Inoue M, Kinoshita H, Kinoshita H, Norimoto M, Norimoto M, Sato T, Sato T, Sato M, Sato M, Suzuki M, Suzuki M, Enomoto K, Enomoto K, Takaoka H, Takaoka H, Mizuki N, Mizuki N, Hozumi T, Hozumi T, Tsuchiya R, Tsuchiya R, Kim G, Kim G, Otagiri T, Otagiri T, Mukaihata T, Mukaihata T, Hishiya T, Hishiya T, Ohtori S, Ohtori S, Inage K, Inage K

Study Design: Prospective cohort study (open-label, single-arm, and non-blinded). Purpose: This study aims to determine the effects of systemic administration of tocilizumab, an anti-interleukin-6 (IL-6) receptor antibody on refractory low back...
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Analysis of Rod Fracture at the Lumbosacral Junction Following Surgery for Adult Spinal Deformity

Sakuma T, Kotani T, Iijima Y, Akazawa T, Ohtori S, Minami S

Study Design: Retrospective study. Purpose: This study aimed to investigate the differences in the characteristics of patients with rod fracture (RF) at the lumbosacral junction from those without RF following adult...
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Efficacy of Platelet-Rich Plasma for Bone Fusion in Transforaminal Lumbar Interbody Fusion

Kubota G, Kamoda H, Orita S, Inage K, Ito M, Yamashita , Furuya T, Akazawa T, Shiga Y, Ohtori S

STUDY DESIGN: Retrospective case series. PURPOSE: To examine the efficacy of platelet-rich plasma (PRP) for bone fusion in transforaminal lumbar interbody fusion (TLIF) using local bone grafting. OVERVIEW OF LITERATURE: Several authors...
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Risk Factors for Loosening of S2 Alar Iliac Screw: Surgical Outcomes of Adult Spinal Deformity

Iijima Y, Kotani T, Sakuma T, Nakayama K, Akazawa T, Kishida S, Muramatsu Y, Sasaki Y, Ueno K, Asada T, Sato K, Minami S, Ohtori S

Study Design: Retrospective study. Purpose: To determine the risk factors for S2 alar iliac (S2AI) screw loosening and its association with lumbosacral fusion in patients with adult spinal deformity (ASD). Overview of...
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Assessment of the Initial Diagnostic Accuracy of a Fragility Fracture of the Sacrum: A Study of 56 Patients

Umeda R, Iijima Y, Yamakawa N, Kotani T, Sakuma T, Kishida S, Ueno K, Kajiwara D, Akazawa T, Shiga Y, Minami S, Ohtori S, Nakagawa K

Study Design: Retrospective study. Purpose: To investigate the clinical manifestations of a fragility fracture of the sacrum (FFS) and the factors that may contribute to a misdiagnosis. Overview of Literature: The number...
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Freeze-Dried Platelet-Rich Plasma Induces Osteoblast Proliferation via Platelet-Derived Growth Factor Receptor-Mediated Signal Transduction

Kinoshita , Orita S, Inage K, Fujimoto K, Shiga Y, Abe K, Inoue M, Norimoto M, Umimura T, Ishii T, Yonemoto T, Kamoda H, Tsukanishi T, Suzuki M, Hirosawa N, Akazawa T, Ohtori S

Study Design: Controlled laboratory study. Purpose: This study aimed to evaluate the in vitro pharmacological activity of growth factors (GFs) in freeze-dried platelet-rich plasma (FD-PRP) after storage for 4 weeks. Overview of...
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Association between Osteoporosis and Skeletal Muscle Mass in Men

Mizutani M, Eguchi Y, Toyoguchi T, Orita S, Inage K, Shiga Y, Maki S, Nakamura J, Hagiwara S, Aoki Y, Inoue M, Koda M, Takahashi H, Akazawa T, Ohtori S

Study Design: Cross-sectional study. Purpose: This cross-sectional study aimed to investigate the risk factors for osteoporosis in men by assessing bone mineral density (BMD), skeletal muscle mass, body fat mass, grip...
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Time-Course Changes in Bone Metabolism Markers and Density in Patients with Osteoporosis Treated with Romosozumab: A Multicenter Retrospective Study

Inage K, Orita S, Eguchi Y, Shiga Y, Koda M, Aoki Y, Kotani T, Akazawa T, Furuya T, Nakamura J, Takahashi H, Suzuki-Narita M, Maki S, Hagiwara S, Inoue M, Norimoto M, Kinoshita H, Sato T, Sato M, Enomoto K, Takaoka H, Mizuki N, Hozumi T, Tsuchiya R, Kim G, Otagiri T, Mukaihata T, Hishiya T, Ohtori S

Purpose: In this multicenter retrospective observational study, we examined the early effects of romosozumab in patients with severe osteoporosis in terms of time-course changes in bone metabolism marker, improvement in...
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Relationship between Skeletal Muscle Mass, Bone Mineral Density, and Trabecular Bone Score in Osteoporotic Vertebral Compression Fractures

Tokeshi S, Eguchi Y, Suzuki M, Yamanaka H, Tamai H, Orita S, Inage K, Shiga Y, Hagiwara S, Nakamura J, Akazawa T, Takahashi H, Ohtori S

Study Design A retrospective observational study was performed. Purpose We investigated the relationships between skeletal muscle mass, bone mineral density (BMD), and trabecular bone score (TBS) in patients with osteoporotic vertebral compression fractures...
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Hooks at the Upper Instrumented Vertebra Can Adjust Postoperative Shoulder Balance in Patients with Adolescent Idiopathic Scoliosis: 5 Years or More of Follow-up

Kuroya S, Akazawa T, Kotani T, Sakuma T, Minami S, Torii Y, Umehara T, Iinuma M, Murakami K, Orita S, Inage K, Eguchi Y, Fujimoto K, Shiga Y, Nakamura J, Inoue G, Miyagi M, Saito W, Ohtori S, Niki H

STUDY DESIGN: A retrospective cohort study. PURPOSE: This study aims to investigate postoperative shoulder imbalance (PSI) ≥5 years postoperatively in patients who underwent posterior spinal fusion using hooks at the upper...
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Usefulness of Simultaneous Magnetic Resonance Neurography and Apparent T2 Mapping for the Diagnosis of Cervical Radiculopathy

Enomoto K, Eguchi Y, Sato T, Norimoto M, Inoue M, Watanabe A, Sakai T, Yoneyama M, Aoki Y, Orita S, Narita M, Inage K, Shiga Y, Umimura T, Sato M, Suzuki M, Takaoka H, Mizuki N, Kim G, Hozumi T, Hirosawa N, Furuya T, Maki S, Nakamura J, Hagiwara S, Koda M, Akazawa T, Takahashi H, Takahashi K, Ohtori S

Study Design: Retrospective observational study. Purpose: We investigated the correlation between T2 relaxation times and clinical symptoms in patients with cervical radiculopathy caused by cervical disk herniation. Overview of Literature: There are...
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Bone Mineral Density and Physical Performance of Female Patients 27 Years or Longer after Surgery for Adolescent Idiopathic Scoliosis

Akazawa T, Kotani T, Sakuma T, Katogi T, Minami S, Niki H, Torii Y, Morioka S, Orita S, Inage K, Fujimoto K, Shiga Y, Takahashi , Ohtori S

STUDY DESIGN: Retrospective cohort study. PURPOSE: To assess bone mineral density (BMD) and bone metabolism ≥27 years after surgery in female patients who underwent spinal fusion for adolescent idiopathic scoliosis (AIS)...
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Use of Bioelectrical Impedance Analysis for the Measurement of Appendicular Skeletal Muscle Mass/Whole Fat Mass and Its Relevance in Assessing Osteoporosis among Patients with Low Back Pain: A Comparative Analysis Using Dual X-ray Absorptiometry

Fujimoto K, Inage K, Eguchi Y, Orita S, Suzuki M, Kubota G, Sainoh T, Sato J, Shiga Y, Abe K, Kanamoto H, Inoue M, Kinoshita , Norimoto M, Umimura T, Koda M, Furuya T, Akazawa T, Toyoguchi , Terakado A, Takahashi , Ohtori S

STUDY DESIGN: Cross-sectional observational study. PURPOSE: To compare measurements of appendicular skeletal muscle mass (ASMM) and whole fat mass (WFM) obtained using dualenergy X-ray absorptiometry (DXA) and bioelectrical impedance analysis (BIA)...
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