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6-Shogaol and 10-Shogaol Synergize Curcumin in Ameliorating Proinflammatory Mediators via the Modulation of TLR4/TRAF6/ MAPK and NFκB Translocation

Zhou X, Al-Khazaleh A, Afzal S, Kao MH(, Münch G, Wohlmuth H, Leach D, Low M, Li CG

Extensive research supported the therapeutic potential of curcumin, a naturally occurring compound, as a promising cytokinesuppressive anti-inflammatory drug. This study aimed to investigate the synergistic anti-inflammatory and anti-cytokine activities by...
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Immune-related therapeutics: an update on antiviral drugs and vaccines to tackle the COVID-19 pandemic

Mir I, Aamir S, Hussain Shah SR, Shahid M, Amin I, Afzal S, Nawaz A, Umer Khan M, Idrees M

The coronavirus disease 2019 (COVID-19) pandemic rapidly spread globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, is a positive-sense single-stranded RNA virus with a reported fatality rate...
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Seroprevalence and Spatial Distribution of Toxoplasmosis in Sheep and Goats in North-Eastern Region of Pakistan

Ahmed H, Malik A, Mustafa I, Arshad M, Khan MR, Afzal S, Ali S, Hashmi MM, Simsek S

Toxoplasmosis is a protozoan disease that is caused by Toxoplasma gondii in livestock and humans. Due to its medical and veterinary importance, it is essential to study the seroprevalence of...
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A novel anti-IL4Rα nanoparticle efficiently controls lung inflammation during asthma

Halwani R, Sultana Shaik A, Ratemi E, Afzal S, Kenana R, Al-Muhsen , Al Faraj A

Drug resistance and the harmful side effects accompanying the prolonged corticosteroid treatment of chronic pulmonary diseases prompted the development of more specific anti-inflammatory approaches. Several strategies aiming to block IL4Rα,...
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