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Adiponectin and thiazolidinedione targets CRTC2 to regulate hepatic gluconeogenesis

Yoon YS, Ryu D, Lee MW, Hong S, Koo SH

During fasting periods, hepatic glucose production is enhanced by glucagon to provide fuels for other organs. This process is mediated via cAMP-dependent induction of the CREB regulated transcriptional coactivator (CRTC)...
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Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro

Stogbauer , Weigert J, Neumeier M, Wanninger , Sporrer D, Weber M, Schaffler , Enrich C, Wood P, Grewal T, Aslanidis , Buechler C

Adiponectin stimulates cholesterol efflux in macrophages and low adiponectin may in part contribute to disturbed reverse cholesterol transport in type 2 diabetes. Monocytes express high levels of annexin A6 that...
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