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Impact of delayed graft function on clinical outcomes in highly sensitized patients after deceased-donor kidney transplantation

Kim SG, Hong S, Lee H, Eum SH, Kim YS, Jin K, Han S, Yang CW, Park WY, Chung BH

Background: We investigated whether the development of delayed graft function (DGF) in pre-sensitized patients affects the clinical outcomes after deceased-donor kidney transplantation (DDKT). Methods: The study included 709 kidney transplant recipients...
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Comparison of Transplant Outcomes for Low-level and Standard-level Tacrolimus at Different Time Points after Kidney Transplantation

Jung HY, Cho SY, Choi JY, Cho JH, Park SH, Kim YL, Kim HK, Huh S, Won DI, Kim CD

BACKGROUND: Optimal tacrolimus (TAC) trough levels for different periods after kidney transplantation (KT) has not been definitely established. This study aimed to investigate transplant outcomes of low-level (LL) and standard-level...
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Clinical Outcomes and Contributors in Contemporary Kidney Transplantation: Single Center Experience

Ahn JS, Park KS, Park J, Chung HC, Park H, Park SJ, Cho HR, Lee JS

BACKGROUND: In recent years, introduction of novel immunosuppressive agents and its proper implementation for clinical practice have contributed to improving clinical outcomes of kidney transplantation (KT). Here, we report clinical...
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Evaluation of Digital PCR as a Technique for Monitoring Acute Rejection in Kidney Transplantation

Lee H, Park YM, We YM, Han DJ, Seo JW, Moon H, Lee YH, Kim YG, Moon JY, Lee SH, Lee JK

Early detection and proper management of kidney rejection are crucial for the long-term health of a transplant recipient. Recipients are normally monitored by serum creatinine measurement and sometimes with graft...
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Interleukin-10 polymorphism (-1082, G/A) on acute rejection risk in solid organ transplant recipients in a Caucasian population: a meta-analysis

Jang HM

Cytokines may play an important role in the acute rejection (AR) of solid organ transplantation. Many studies have investigated the association between interleukin-10 gene (IL-10) polymorphisms and risk of AR....
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Outcomes for patients with HCV after liver transplantation in Korea: a multicenter study

Kim JM, Lee KW, Song GW, Jung BH, Lee HW, Yi NJ, Kwon CH, Hwang S, Suh KS, Joh JW, Lee SK, Lee SG

PURPOSE: HCV-related liver disease is the most common indication for liver transplantation (LT) in Western countries, whereas HCV LT is rare in Korea. We conducted a survey of HCV RNA-positive...
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The impact of early and late acute rejection on graft survival in renal transplantation

Koo EH, Jang HR, Lee JE, Park JB, Kim SJ, Kim DJ, Kim YG, Oh HY, Huh W

BACKGROUND: Advances in immunosuppression after kidney transplantation have decreased the influence of early acute rejection (EAR) on graft survival. Several studies have suggested that late acute rejection (LAR) has a...
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Effect of donor-specific antibodies and panel reactive antibodies in living donor liver transplant recipients

Song SH, Kim MS, Lee JJ, Ju MK, Lee JG, Lee J, Choi JS, Choi GH, Kim SI, Joo DJ

PURPOSE: Preformed circulating donor-specific antibodies (DSAs) immunologically challenge vascular endothelium and the bile duct. However, the liver is an immune-tolerant organ and can avoid immunological challenges. This study was undertaken...
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Safety and Efficacy of Conversion from Twice-Daily Tacrolimus to Once-Daily Tacrolimus One Month after Transplantation: Randomized Controlled Trial in Adult Renal Transplantation

Oh CK, Huh KH, Lee JS, Cho HR, Kim YS

PURPOSE: The purpose of this study was to compare once-daily tacrolimus with twice-daily tacrolimus in terms of safety, efficacy, and patient satisfaction. MATERIALS AND METHODS: This prospective, randomized, open-label, multicenter study...
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Impact of Combined Acute Rejection on BK Virus-Associated Nephropathy in Kidney Transplantation

Kim YJ, Jeong JC, Koo TY, Kwon HY, Han M, Jeon HJ, Ahn C, Yang J

BK virus-associated nephropathy (BKVAN) is one of the major causes of allograft dysfunction in kidney transplant (KT) patients. We compared BKVAN combined with acute rejection (BKVAN/AR) with BKVAN alone in...
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The effect of a positive T-lymphocytotoxic crossmatch on clinical outcomes in adult-to-adult living donor liver transplantation

Kim YK, Kim SH, Moon IS, Han SS, Cho SY, You T, Park SJ

PURPOSE: There is controversy concerning the effect of a positive T-lymphocytotoxic crossmatch (TLC) on clinical outcomes in adult living donor liver transplantation (LDLT). The aim of this study was to...
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A Case Report of Kidney Graft Failure after Duodenal Bypass Surgery

Kim HN, Cho YH, Kim YS, Chun HJ, Choi SJ, Kim EO, Yang CW

  • KMID: 2263460
  • Korean J Med.
  • 2012 Sep;83(3):369-372.
The calcineurin inhibitor-immunosuppressant tacrolimus is widely used in patients undergoing kidney transplantation. Although tacrolimus is absorbed from the entire gastrointestinal tract, the duodenum is the primary site of its absorption...
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Prospective Controlled Protocol for Three Months Steroid Withdrawal with Tacrolimus, Basiliximab, and Mycophenolate Mofetil in Renal Transplant Recipients

Oh CK, Kim SJ, Kim JH, Lee JH

During the past few years, new immunosuppressants, such as tacrolimus, mycophenolate mofetil (MMF) and basiliximab, have been shown to successfully decrease the incidence of acute rejection, possibly acting as potent...
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Optimized Tacrolimus Therapy in the Early Stage after Renal Transplantation

Min SI, Kim SY, Ahn SH, Chung CK, Min SK, Ha J, Kim SJ

PURPOSE: Immunosuppressive regimen based on reduced-dose Tacrolimus (TAC) is widely accepted in the field of renal transplantation. However, optimal targetsfor TAC whole blood trough concentrations during the early period after...
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Does Calcineurin Inhibitor Plus Mycophenolate Mofetil Combination Therapy Decrease the Risk of Late Acute Rejection after Liver Transplantation?

Kim KW, Lee SG, Hwang S, Kim KH, Ahn CS, Moon DB, Ha TY, Song GW, Jung DH, Choi NK, Park JI, Park GC, Yu YD, Park PJ, Choi YI

BACKGROUND: With advances in immunosuppression, graft and patient survival rates have increased significantly, but acute cellular rejection remains an important problem following liver transplantation (LT), and late acute rejection (LAR)...
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The Risk Factors of Acute Cellular Rejection in Adult Living Donor Liver Transplantation:Doubting the Value of Positive Lymphocytotoxic Cross-match Results

Jung KU, Park JB, Kim JM, Moon JI, Jung GO, Chun JM, Choi GS, Kwon CD, Kim SJ, Joh JW, Lee SK

BACKGROUND: The influence of lymphocytotoxic cross-match results on acute cellular rejection in adult living donor liver transplantation (LDLT) has not been well examined. Therefore, in this study, we investigated the...
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The Expression of C4d and CD20 in Graft Kidney with Acute Rejection

Kim JH, Oh HJ, Son YK, Park YK, Sin YH, Kim JK, Kang WG, Lee SS, Hur K, Chang HK

  • KMID: 2201916
  • J Korean Soc Transplant.
  • 2008 Jun;22(1):49-57.
PURPOSE: The presence of C4d in peritubular capillaries (C4d (PTC)) as a diagnostic in-situ marker of acute humoral rejection and CD20 as marker of B-cell deposition in graft kidney has...
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Effect of High Dose Intravenous Immunoglobulins on the Treatment of Antibody Mediated Humoral Rejection and BK Virus Infection in Renal Transplant Recipients

Lee JS, Jeon JS, Han DC, Song D, Moon C

  • KMID: 2201866
  • J Korean Soc Transplant.
  • 2007 Jun;21(1):140-142.
Despite the recent advances in immunosuppression, antibody mediated acute rejection is associated with a poor prognosis. Therapeutic interventions such as polyclonal antibodies, rituximab, and plasmapheresis have been used for the...
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Evaluation of Pre- and Post-Transplantation Various Serum Cytokines for Prediction of Liver Allograft Rejection

Kim SJ, Oh EJ, Lee CY, Kim DG

  • KMID: 2201834
  • J Korean Soc Transplant.
  • 2006 Dec;20(2):234-240.
Purpose: The aim of the present study was to identify whether the percentages of T cell subset, the serum interferon-gamma (IFN gamma ) as a Th1 cytokine, soluble CD30 (sCD30)...
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Allograft Rejection after Liver Transplantation in Children

Ko JM, Kim KM, Kim JS, Lee SY, Chang SH, Choi BH, Yoo ES, Ahn CS, Kim KH, Hwang S, Park KM, Lee YJ, Lee SG

  • KMID: 2201777
  • J Korean Soc Transplant.
  • 2005 Jun;19(1):51-57.
PURPOSE: We performed this study to assess the clinical course of acute rejection and chronic rejection after liver transplantation in children. METHODS: Seventy-six liver transplantations were performed in 75 children...
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