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Respiratory Viruses in Acute Exacerbations of Bronchiectasis

Park YE, Sung H, Oh YM

Background: Bacterial infections are well known factors underlying acute exacerbations in bronchiectasis. However, viral infections may also contribute to acute exacerbations. We aimed to assess the rate of viral detection...
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The effects of direct hemoperfusion with polymyxin B-immobilized fiber in patients with acute exacerbation of interstitial lung disease

Lee JH, Park JH, Kim HJ, Kim HK, Jang JH, Kim YK, Park BS, Park SH, Kim IH, Kim SH, Heo W, Jang HJ

Background: Acute exacerbation of interstitial lung disease (AE-ILD) causes clinically significant deterioration and has an extremely poor prognosis with high mortality. Recently, several studies reported the effectiveness of direct hemoperfusion...
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Hyperuricemia Is Not Predictive of Long-Term Outcome in Patients with Stable Chronic Obstructive Pulmonary Disease

Hwang JJ, Oh YM, Rhee CK, Yoo KH, Park YB, Yoon HI, Lim SY, Lee JH, Kim EK, Kim TH, Lee SW, Lee SD, Lee JS, KOLD Group

BACKGROUND: Although the association of hyperuricemia with an increased risk of mortality has been demonstrated in the context of acute exacerbation of chronic obstructive pulmonary disease (COPD), the long-term outcomes...
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Treatment and prevention of acute exacerbation of chronic obstructive pulmonary disease

Lim SY, Kim HJ, Ra SW, Lee JH, Kim TH

Acute exacerbation of chronic obstructive pulmonary disease (COPD) is defined as an acute aggravation of the patient's respiratory symptoms, particularly cough, sputum production, and dyspnea, which requires a change of...
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Desaturaton due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease in the Patient Who Underwent the Cephalic Vein Bypass Surgery under Epidural Anesthesia

Han YM, Kim SH, Yoo JH, Park AY

A 72-year-old man with chronic renal failure underwent cephalic vein bypass surgery. He also had diabetes mellitus, hypertension, and chronic obstructive pulmonary disease. To avoid the exacerbation of chronic obstructive...
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Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations

Kim HJ, Lee J, Kim JH, Park SY, Kwon HS, Kim TB, Moon HB, Cho YS

PURPOSE: Prolonged recovery time of pulmonary function after an asthma exacerbation is a significant burden on asthmatics, and management of these patients needs to be improved. The aim of this...
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Effect of Airflow Limitation on Acute Exacerbations in Patients with Destroyed Lungs by Tuberculosis

Kim SJ, Lee J, Park YS, Lee CH, Lee SM, Yim JJ, Kim YW, Han SK, Yoo CG

History of treatment for tuberculosis (TB) is a risk factor for obstructive lung disease. However, it has been unclear whether the clinical characteristics of patients with destroyed lung by TB...
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Is it necessary to delay antiviral therapy for 3-6 months to anticipate HBeAg seroconversion in patients with HBeAg-positive chronic hepatitis B in endemic areas of HBV genotype C?

Song BC, Cho YK, Jwa H, Choi EK, Kim HU, Song HJ, Na SY, Boo SJ, Jeong SU

BACKGROUND/AIMS: Spontaneous HBeAg seroconversion occurs frequently in the immune reactive phase in HBeAg-positive chronic hepatitis B (CHB). Therefore, observation for 3-6 months before commencing antiviral therapy is recommended in patients...
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Effect of air pollution on acute exacerbation of adult asthma in Seoul, Korea: A case-crossover study

Kim SH, Son JY, Lee JT, Kim TB, Park HW, Lee JH, Kim TH, Sohn JW, Shin DH, Park SS, Yoon HJ

  • KMID: 2259159
  • Korean J Med.
  • 2010 Apr;78(4):450-456.
BACKGROUND/AIMS: Outdoor air pollution is an important risk factor for developing asthma and acute exacerbation. Although some epidemiologic studies have shown that increased levels of air pollutants are linked with...
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The effect of Combination Therapy of Inhaled Corticosteroids and Long-acting Beta2-agonists on Acute Exacerbation in Moderate to Severe COPD Patients

Jeong HC, Ha ES, Jung JY, Lee KJ, Lee SH, Kim SJ, Lee EJ, Hur GY, Lee SY, Kim JH, Lee SY, Shin C, Shim JJ, In KH, Kang KH, Yoo SH

  • KMID: 2318651
  • Tuberc Respir Dis.
  • 2005 Aug;59(2):164-169.
BACKGROUND: The role of combination therapy of inhaled corticosteroid (ICS) plus long-acting beta2-agonist (LABA) in asthma is well established, but nor much is known about this treatment in COPD. Recent...
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Antibiotics in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Kim SK, Kim YS

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States, and is projected to rank fifth in 2020 as a worldwide burden of disease....
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The changing patterns of acute hepatitis B infection in Korea in the early 2000's

Yim HJ, Chang YJ, Byun KS, Suh YS, Kim JH, Kim JY, Yeon JE, Park JJ, Kim JS, Bak YT, Lee CH

  • KMID: 2081167
  • Korean J Med.
  • 2005 Dec;69(6):601-607.
BACKGROUND: The prevalence of the hepatitis B virus (HBV) carrier state in Korean children is markedly reduced after the introduction of routine HBV vaccination program. The aims of this study...
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Prognostic Role of B-type Natriuretic Peptide in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Lee JH, Oh SY, Hwang I, Kim O, Kim HK, Kim EK, Lee JH

BACKGROUND: The plasma B-type natriuretic peptide(BNP) concentration increases with the degree of pulmonary hypertension in patients with chronic respiratory disease. The aim of this study was to examine the prognostic...
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Etiology and Clinical Consequence of Spontaneous Acute Exacerbation of Chronic Hepatitis B

Chae MJ, Kim BH, Jeong KH, Kim NH, Dong SH, Kim HJ, Chang YW, Lee JI, Chang R

  • KMID: 760537
  • Korean J Hepatol.
  • 2004 Jun;10(2):99-107.
BACKGROUND/AIMS: Acute exacerbation (AE) of chronic hepatitis B (CHB) can occur spontaneously, and may be followed by HBeAg clearance. HBeAg seroconversion often coincides with the normalization of liver biochemical...
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In Vitro Activities of Gatifloxacin against Bacteria isolated from Respiratory Specimens of Patients of University Hospitals in Korea

Yong D, Kim M, Kim S, Lee K, Kim S, Chong Y, Lee YS

  • KMID: 2170094
  • Infect Chemother.
  • 2004 Apr;36(2):68-74.
BACKGROUND: Gatifloxacin, a new 8-methoxyquinolone, has a broad-spectrum activity with expanded potency against respiratory pathogens. In this study, we examined the in vitro activity of gatifloxacin and comparators against recently...
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Adequacy of Immediate Lamivudine Trial for Chronic Hepatitis B Patients with Acute Exacerbation

Lee CK, Suh JH, Cho YS, Won SY, Park IS

  • KMID: 760528
  • Korean J Hepatol.
  • 2004 Mar;10(1):22-30.
BACKGROUND/AIMS: It has been unclear whether immediate antiviral therapy or observation under the expectation of spontaneous inactivation of hepatitis B virus (HBV), is more appropriate for the treatment of...
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A Randomized, Double-Blind Study to Assess the Efficacy and Safety of Oral LB20304 (Gemifloxacin) at Doses of 160mg or 320mg (Equivalent to 200mg or 400mg of the Mesylate Salt) Once Daily for 7 Days for the Treatment of Acute Exacerbations of Chronic Bronchitis (AECB) in Korean Adult Population

Kim YW, Shim YS, Kim WD, Shim TS, Kang HM, Choi BW, Kim JY, Kwon OJ, Kim H, Kim JO, Jung KS, Hyeon IG, Mo EK, Lee SJ, Nam GH, Lee KY, Park JS

BACKGROUND: LB20304(gemifloxacin) is a new fluoroquinolone antibacterial agent with excellent activity against both Gram-negative and Gram-positive organisms. In vitro studies using clinical isolates have shown gemifloxacin to be highly active...
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Changes of Sputum Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinase-1 by Antibiotic Treatment in Acute Exacerbation of Chronic Bronchitis

Yoon HK, Ahn JH, Kim CH, Kwon SS, Kim YK, Kim KH, Moon HS, Park SH, Song JS

BACKGROUND: Excessive extracellular matrix (ECM) deposition by airway inflammation is presumed to play an important role in the pathogenesis of worsening airflow obstruction (Ed- acceptable three-word noun) seen during acute...
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A Multicenter, Randomized, Open, Comparative Study for the Efficacy and Safety of Oral Moxifloxacin 400 mg Once a Day and Clarithromycin 500 mg Twice Daily in Korean Patients with Acute Exacerbations of Chronic Bronchitis

Kim SJ, Kim SC, Lee SY, Yoon HK, Kim TY, Kim YK, Song JS, Park SH, Kim HJ, Chung MP, Suh GY, Kwon OJ, Lee SH, Kang KH, Lee EH, Hwang SC, Ha MH

BACKGROUND: Moxifloxacin is a newly developed drug which is more potent and safe compared to previous fluoroquinolones. This drug effectively eradicates organisms such as beta-lactamase-producing or other resistant bacteria. Moxifloxacin...
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