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Inhibitory effects of osteoprotegerin on osteoclast formation and function under serum-free conditions

Fu YX, Gu JH, Zhang YR, Tong XS, Zhao HY, Yuan Y, Liu XZ, Bian JC, Liu ZP

The purpose of this study was to determine whether osteoprotegerin (OPG) could affect osteoclat differentiation and activation under serum-free conditions. Both duck embryo bone marrow cells and RAW264.7 cells were...
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Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species

Moon HJ, Kim SE, Yun YP, Hwang YS, Bang JB, Park JH, Kwon IK

Osteoclasts, together with osteoblasts, control the amount of bone tissue and regulate bone remodeling. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. Reactive oxygen...
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