- Rapid increase of cytosolic content of acetyl-CoA carboxylase isoforms in H9c2 cells by short-term treatment with insulin and okadaic acid
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Park CE, Ko SM, Kim JM, Yoon MY, Kim JY, Kang IS, Kim SS, Ha JH
- KMID: 754991
- Exp Mol Med.
- 1998 Jun;30(2):73-79.
Mammalian acetyl-CoA carboxylase (ACC) is present in two isoforms, alpha and beta, both of which catalyze formation of malonyl-CoA by fixing CO2 into acetyl-CoA. ACC-alpha is highly expressed in lipogenic tissues whereas... -
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- Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha
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Qiang W, Weiqiang K, Qing Z, Pengju Z, Yi L
- KMID: 756077
- Exp Mol Med.
- 2007 Aug;39(4):535-543.
Insufficient intracellular fat oxidation is an important contributor to aging-related insulin resistance, while the precise mechanism underlying is unclear. AMP-activated protein kinase (AMPK) is an important regulator of intracellular fat... -
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