- Spinal Gabapentin and Antinociception: Mechanisms of Action
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Yoon MH, Choi JI, Jeong SW
- KMID: 2157631
- J Korean Med Sci.
- 2003 Apr;18(2):255-261.
- doi: 10.3346/jkms.2003.18.2.255
Spinal gabapentin has been known to show the antinociceptive effect. Although several assumptions have been suggested, mechanisms of action of gabapentin have not been clearly established. The present study was... -
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- The Effect of Intrathecal Gabapentin on Mechanical and Thermal Hyperalgesia in Neuropathic Rats Induced by Spinal Nerve Ligation
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Cho HS, Kim MH, Choi DH, Lee JI, Gwak MS, Hahm TS
- KMID: 648681
- J Korean Med Sci.
- 2002 Apr;17(2):225-229.
- doi: 10.3346/jkms.2002.17.2.225
Gabapentin decreases the level of glutamate and elevates that of garmma-amino-butyric acid in the central nervous system. Gabapentin was shown to have antinociceptive effects in several facilitated pain models. Intrathecal... -
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