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A Rare Case of Overlap Syndrome with Diffuse Systemic Sclerosis, Rheumatoid Arthritis, and Cutaneous Sarcoidosis

Ko KM, Moon SJ, Koh JH, Kim J, Min JK

Overlap syndrome is defined as a disease entity that satisfies the classification criteria of at least two connective tissue diseases occurring concurrently or separately in a single patient. Here, we...
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Transaminase Changes in Korean Rheumatoid Arthritis Patients with Chronic Hepatitis C after Biologic Therapy

Kwon HM, Shin K, Moon JY, Lee SS, Chung WT, Lee J, Lee SH, Kang SW, Suh CH, Hong SJ, Song R, Choe JY, Song YW

OBJECTIVE: Coexisting chronic hepatitis C can be problematic when treating rheumatoid arthritis (RA). This study examined the changes in the transaminase and viral load in hepatitis C virus (HCV)-infected RA...
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Vaccination for Patients with Rheumatic Diseases in the Era of Biologics

Han SH

A large proportion of patients with rheumatic disease have an immunocompromised status resulting from disease pathogenesis itself and/or several immunosuppressive drugs including biologics. These conditions are closely related to a...
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dNP2-ctCTLA-4 inhibits German cockroach extract-induced allergic airway inflammation and hyper-responsiveness via inhibition of Th2 responses

Lim S, Sohn JH, Koo JH, Park JW, Choi JM

German cockroaches are major household allergens that can trigger allergic airway inflammatory diseases with sensitive T-cell responses. Although the use of immune modulatory biologics, such as antibodies, to mediate allergic...
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Risk of Herpes Zoster in Patients with Rheumatoid Arthritis Undergoing Biologic Disease-Modifying Therapy

Kwon HM, Lee SJ, Yang JA, Choi Y, Park JK, Lee EY, Song YW, Lee EB

OBJECTIVE: Rheumatoid arthritis (RA) patients suffer from an increased risk of herpes zoster (HZ) partially due to immunosuppressant medications. This study investigated HZ in RA patients treated with biologic disease-modifying...
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Cost-Minimization Analysis of Biologic Disease-Modifying Antirheumatic Drugs Administered by Subcutaneous Injections in Patients with Rheumatoid Arthritis

Park SH, Lee MY, Lee EK

BACKGROUND: The subcutaneous formulation of biologic disease-modifying antirheumatic drugs (DMARDs) was preferred due to favored self-administration and would be an economical treatment option for patients with rheumatoid arthritis. This study...
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Overcome of Drug Induced Thrombotic Microangiopathy after Kidney Transplantation by Using Belatacept for Maintenance Immunosuppression

Yun SH, Lee JH, Oh JS, Kim SM, Sin YH, Kim YJ, Kim JK

Thrombotic microangiopathy (TMA) is a serious complication of solid organ transplantation. Drug-induced TMA is typically caused by immunosuppressants, particularly calcineurin inhibitors. Withdrawing the causative drug can be one of the...
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Comparative Effectiveness of Biologic DMARDs in Rheumatoid Arthritis Patients with Inadequate Response to conventional DMARDs: Using a Bayesian Network Meta-analysis

Park SK, Kim HL, Lee MY, Kim A, Lee EK

BACKGROUND: Biologic disease-modifying antirheumatic drugs (bDMARDs) extend the treatment choices for rheumatoid arthritis patients with insufficient response or intolerance to conventional DMARDs (cDMARDs). These agents have considerable efficacy compared with...
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Long Term Safety and Efficacy of Abatacept in Patients with Rheumatoid Arthritis

Lee CK

No abstract available.
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Long-term Safety and Efficacy of Abatacept in Koreans with Rheumatoid Arthritis

Shim SC, Park SH, Bae SC, Choe JY, Song YW, Mitra P, Karyekar C

OBJECTIVE: The safety and efficacy of intravenous (IV) abatacept in patients with active RA unresponsive to methotrexate have been demonstrated in short-term (ST) studies in global populations and a ST,...
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New drugs for Rheumatoid arthritis

Seo YI

  • KMID: 2257380
  • Korean J Med.
  • 2009 Jan;76(1):12-17.
Since the late 1990s, based on scientific advancement and biotechnological improvement, many effective drugs such as leflunomide and biologic agents for rheumatoid arthritis (RA) have been developed. These include TNF-alpha...
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Human Cytotoxic T Lymphocyte-associated Antigen 4-immunoglobulin Fusion Protein Inhibits Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma

  • KMID: 2234531
  • Korean J Asthma Allergy Clin Immunol.
  • 2008 Sep;28(3):205-213.
BACKGROUND: CD4+ T helper cells which differentiate into the Th2 cells are crucial for the initiation and progression of allergic asthma. Human Cytotoxic T Lymphocyte- associated Antigen 4-immunoglobulin (CTLA4-Ig) has...
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Alteration of Molecules and Cytokines Related to the Activation of T Lymphocyte in Immune Tolerance Induced Mice Model

Hur SM, Kwon CH, Joh JW, Kim SJ

  • KMID: 2201804
  • J Korean Soc Transplant.
  • 2005 Dec;19(2):119-123.
PURPOSE: Monoclonal antibodies (mAb) specific for CD45RB as a potent tolerogenic target can prolong allograft survival in several animal models. The mechanisms of CD45RB mAb-mediated tolerance are largely unknown. Therefore,...
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Biologic Therapy in Rheumatoid Arthritis

Koh EM

  • KMID: 2168065
  • Hanyang Med Rev.
  • 2005 May;25(2):80-88.
Rheumatoid arthritis (RA) is a common autoimmune disease of unknown etiology characterized by symmetric and erosive synovitis. The course of RA is usually chronic and progressive, so it can result...
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Inhibitory effects of CTLA4-Ig fusion protein on the proliferation of T cell and the antibody production of B cell

Jang SO, Lee SY, Hong SJ

  • KMID: 2178421
  • J Asthma Allergy Clin Immunol.
  • 2003 Dec;23(4):818-825.
BACKGROUND: Atopic asthma is characterized by activation of Th2-type T cells in the bronchial mucosa. Several reports have suggested an important role for costimulation through the CD28/CTLA4 (cytotoxic T lymphocyte-associated...
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