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Rac-mediated actin remodeling and myosin II are involved in KATP channel trafficking in pancreatic beta-cells

Han YE, Lim A, Park SH, Chang S, Lee SH, Ho WK

AMP-activated protein kinase (AMPK) is a metabolic sensor activated during metabolic stress and it regulates various enzymes and cellular processes to maintain metabolic homeostasis. We previously reported that activation of...
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Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro

Stogbauer , Weigert J, Neumeier M, Wanninger , Sporrer D, Weber M, Schaffler , Enrich C, Wood P, Grewal T, Aslanidis , Buechler C

Adiponectin stimulates cholesterol efflux in macrophages and low adiponectin may in part contribute to disturbed reverse cholesterol transport in type 2 diabetes. Monocytes express high levels of annexin A6 that...
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Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model

Moon MH, Jeong JK, Lee JH, Park YG, Lee YJ, Seol JW, Park SY

  • KMID: 1506224
  • Exp Mol Med.
  • 2012 Oct;44(10):603-614.
Higher levels of body fat are associated with an increased risk for development numerous adverse health conditions. FTY720 is an immune modulator and a synthetic analogue of sphingosine 1-phosphate (S1P),...
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