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Thrombotic thrombocytopenic purpura in three pregnancies

Yoon WS, Lee JW, Kim YH, Ahn HY, Shin JC

Thromobotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS), characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, central nervous system abnormalities, and renal dysfunction, is severe multisystem disorder. TTP-HUS occurs predominantly in the reproductive...
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Frequency of Pro475Ser Polymorphism of ADAMTS13 Gene and Its Association with ADAMTS-13 Activity in the Korean Population

Jang MJ, Kim NK, Chong SY, Kim HJ, Lee SJ, Kang MS, Oh D

PURPOSE: The in vitro study suggested that proline to serine polymorphism in codon 475 (C1423T) of the A Disintegrin and Metalloprotease with ThromboSpondin type 1 repeats-13 (ADAMTS-13) gene is related...
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Hemolytic uremic syndrome

Park HW

The hemolytic uremic syndrome (HUS) is a rare disease of microangiopathic hemolytic anemia, low platelet count and renal impairment. HUS usually occurs in young children after hemorrhagic colitis by shigatoxin-producing...
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A Splenectomy in Plasma Exchange Refractory Thrombotic Thrombocytopenia Purpura

Lee YJ, Shim H, Park DE

Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, and variable abnormalities in renal function and mental status. The pathogenesis of TTP is related to an inhibitor...
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The Usefulness of the New ADAMTS-13 Activity Assay using a Fluorescence-quenching Substrate for the Diagnosis of Thrombotic Thrombocytopenic Purpura

Jang MJ, Oh SY, Chong SY, Kang MS, Oh D

BACKGROUND: Ever since medical professionals have recognized the important role of ADAMTS-13 in the pathogenesis of TTP, several methods to diagnosis the activity of ADAMTS-13 in the plasma of TTP...
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Changes of the Activity of ADAMTS-13 in aging, Pregnancy and Disease

Jang MJ, Chong SY, Lee SJ, Kim NK, Kang MS, Oh D

  • KMID: 2252533
  • Korean J Hematol.
  • 2004 Jun;39(2):71-77.
BACKGROUND: ADAMTS-13 is an enzyme that has function of cleaving von Willebrand factor multimer to monomer at normal plasma level. We have previously reported that the activity of ADAMTS-13 is...
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