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Urushiol V Suppresses Cell Proliferation and Enhances Antitumor Activity of 5-FU in Human Colon Cancer Cells by Downregulating FoxM1

Jeong JH, Ryu JH

Colorectal cancer (CRC) is one of the most common malignant tumor. 5-FU is commonly used for the treatment of CRC. However, the development of drug resistance in tumor chemotherapy can...
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ER71/ETV2 Promotes Hair Regeneration from Chemotherapeutic Drug-Induced Hair Loss by Enhancing Angiogenesis

Lee TJ, Kang HK, Berry JC, Joo HG, Park C, Miller MJ, Choi K

Chemotherapy-induced alopecia and hair loss can be stressful in patients with cancer. The hair grows back, but sometimes the hair tends to stay thin. Therefore, understanding mechanisms regulating hair regeneration...
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Acute Aortic Thrombosis Following Capecitabine Chemotherapy in a Patient with Colon Cancer

Lee MK, Kim EY, Kim YS, Sym SJ, Kim JH

The elevated risk for thromboembolic events in cancer patients has been well documented. Chemotherapy is considered to be one of the most important risk factors for cardiovascular complications such as...
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Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells

Yao CW, Kang KA, Piao MJ, Ryu YS, Fernando P, Oh MC, Park JE, Shilnikova K, Na SY, Jeong SU, Boo SJ, Hyun JW

We investigated the role of autophagy in SNUC5/5-FUR, 5-fluorouracil (5-FU) resistant SNUC5 colon cancer cells. SNUC5/5-FUR cells exhibited low level of autophagy, as determined by light microscopy, confocal microscopy, and...
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Clinical implications of APEX1 and Jagged1 as chemoresistance factors in biliary tract cancer

Kim HB, Cho WJ, Choi NG, Kim SS, Park JH, Lee HJ, Park SG

PURPOSE: Biliary cancer is a highly malignant neoplasm with poor prognosis and most patients need to undergo palliative chemotherapy, however major clinical problem associated with the use of chemotherapy is...
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Sensitization of 5-Fluorouracil-Resistant SNUC5 Colon Cancer Cells to Apoptosis by α-Mangostin

Lee J, Kang JS, Choi BY, Keum YS

5-fluorouracil (5-FU) is a chemotherapeutic agent commonly used for treatment of solid tumors, including colorectal cancer. However, chemoresistance against 5-fluorouracil (5-FU) often limits its success for chemotherapy and, therefore, finding...
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Effect of 5-FU and MTX on the Expression of Drug-resistance Related Cancer Stem Cell Markers in Non-small Cell Lung Cancer Cells

Yi H, Cho HJ, Cho SM, Jo K, Park JA, Lee SH, Chang BJ, Kim JS, Shin HC

Cancer stem cells (CSCs) are often characterized by the elevated expression of drug-resistance related stem-cell surface markers, such as CD133 and ABCG2. Recently, we reported that CSCs have a high...
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A Case of Radiation Recall Myositis Induced by 5-FU and Cisplatin

Ryu YS, Jeon CH

Radiation recall phenomenon is an inflammatory reaction which occurs at a previously irradiated area after the administration of causative agents, especially anticancer drugs. Radiation recall mostly involves skin and rarely...
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Ahmed Valve Implantation with Adjunctive Mitomycin C and 5-Fluorouracil: Outcomes at 2 Years

Lim SH, Seo WM, Park JJ, Yun SU

PURPOSE: To evaluate the outcomes of Ahmed valve implantation in neovascular glaucoma patients who received intraoperative mitomycin C (MMC) and postoperative 5-fluorouracil (5-FU) after 24 months of follow-up. METHODS: A total...
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Docetaxel, Cisplatin, 5-FU Combination Chemotherapy as a First-Line Treatment in Patients with Advanced Gastric Cancer

Kim BK, Park MI, Park SJ, Kim KJ, Moon W, Jeong SH, Kim HS, Nam SJ

  • KMID: 2259291
  • Korean J Med.
  • 2011 Jun;80(6):680-686.
BACKGROUND/AIMS: This study investigated the efficacy and safety of docetaxel/cisplatin/5-fluorouracil (DCF) combination chemotherapy as a first-line treatment in patients with advanced gastric cancer. METHODS: The study enrolled 48 patients diagnosed with...
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Onset of Manic Episode during Chemotherapy with 5-Fluorouracil

Ha JH, Hwang DY, Yu J, Park DH, Ryu SH

  • KMID: 2315932
  • Psychiatry Investig.
  • 2011 Mar;8(1):71-73.
The authors report a case of 5-Fluorouracil (5-FU) induced manic episode in an elderly female without any previous psychiatric history. The patient presented manic symptoms after 4th cycle of 5-FU...
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Triamcinolone and 5-Fluorouracil to Manage the Burn Hypertrophic Scar

Jang KU, Lee JY, Choi JS, Moon JH, Jeon JH, Seo CH

  • KMID: 2117472
  • J Korean Burn Soc.
  • 2010 Dec;13(2):124-128.
PURPOSE: The purpose of this research is to evaluate the efficacy and side effect of 5-Fluorouracil (5-FU) and Triamcinolone (TA) as a therapeutic agent in the treatment of burn hypertrophic...
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A Case of Corneal Endothelial Damage by 5-Fluorouracil Inflow Into Anterior Chamber After Subconjunctival Injection

Kim DH, Kim MH, Ahn JH

PURPOSE: To present a case of corneal endothelial damage caused by inflow of 5-FU after subconjunctival 5-FU injection in a patient undergoing trabeculectomy. CASE SUMMARY: A 65-year-old female patient diagnosed with...
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A Case of 5-Fluorouracil Induced Encephalopathy

Kwon KA, Kwon HC, Kim MC, Kim SH, Oh SY, Lee S, Kim HJ

  • KMID: 2165968
  • Cancer Res Treat.
  • 2010 Jun;42(2):118-120.
Patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at risk for experiencing serious adverse effects following 5-fluorouracil (5-FU) based chemotherapy. Neurotoxicity is considered an extremely rare side effect of 5-FU....
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A case of microinvasive Paget's disease of the vulva: Treatment of positive resection margin with topical 5-FU cream application

Kang HJ, Park CM, Shim SS, Son YS, Kim SY

  • KMID: 1475017
  • Korean J Obstet Gynecol.
  • 2009 Mar;52(3):372-376.
Extramammary Paget's disease of the vulva is a rare lesion that accounts for 1~2% of vulvar neoplasms. Paget's disease often has a microscopic extension beyond the gross lesion and shows...
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Docetaxel-Cisplatin-5-FU Combination Chemotherapy as a First-line Treatment in Patients with Metastatic or Recurred Gastric Cancer

Kang SH, Kim JI, Goh PG, Hwang SW, Kwon DS, Nam KW, Kang HM, Kang YS, Moon HS, Kim SH, Seong JK, Lee BS, Jeong HY

  • KMID: 782906
  • Korean J Gastroenterol.
  • 2007 Sep;50(3):157-163.
BACKGROUND/AIMS: The purpose of this study was to investigate the efficacy and safety of 'docetaxel-5-FU-cisplatin' combination chemotherapy as a first-line treatment in patients with metastatic or recurrent gastric cancer. ...
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Irinotecan, Continuous 5-Fluorouracil, and Low dose of Leucovorin (modified FOLFIRI) as First Line of Therapy in Recurrent or Metastatic Colorectal Cancer

Lee MA, Byun JH, Shim BY, Woo IS, Kang JH, Hong YS, Lee KS, Choi MG, Chang SK, Oh ST, Choi SI, Lee DS

BACKGROUND: Irinotecan, in combination with 5-fluorouracil (5-FU) and a high dose of leucovorin (LV), known as FOLFIRI regimen, has shown activity in recurrent or metastatic colorectal cancer. Therefore, we evaluated...
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A Phase II Trial of Haptaplatin/5-FU and Leucovorin for Advanced Stomach Cancer

Lee WS, Lee GW, Kim HW, Lee OJ, Lee YJ, Ko GH, Lee JS, Jang JS, Ha WS

  • KMID: 1804572
  • Cancer Res Treat.
  • 2005 Aug;37(4):208-211.
PURPOSE: Heptaplatin (SKI-2053 R) is a new platinum analogue, with a better toxicity profile than cisplatin, and has antitumor activity even in cisplatin resistant cell lines. 5-fluoruracil (5-FU) has shown...
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Adjuvant Effect of NSAIDs on the Cytotoxicity of Colon Cancer Cells to 5-FU

Lee TB, Kim KJ, Min YD, Kang SI, Jung KR, Lee JU, Choi CH

  • KMID: 2101387
  • J Korean Soc Coloproctol.
  • 2005 Jun;21(3):121-128.
PURPOSE: Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the conversion of arachidonic acid to prostaglandins, is believed to be an important enzyme related to colorectal cancer. A large number of...
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Efficacy of Hepatic Arterial Infusion Therapy for Advanced Hepatocellular Carcinoma Using 5-Fluorouracil, Epirubicin and Mitomycin-C

Hwang JY, Jang BK, Kwon KM, Chung WJ, Park KS, Cho KB, Hwang JS, Ahn SH, Kim GC, Kim YH, Choi JS, Kwon JH

  • KMID: 2439746
  • Korean J Gastroenterol.
  • 2005 Feb;45(2):118-124.
BACKGROUND/AIMS: Prognosis of advanced hepatocellular carcinoma (HCC) treated by conventional therapies has been considered to be poor. The aim of this study was to evaluate the efficacy of hepatic...
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