- Inhibitory Effect of Rotundarpene on Parkinsonian Neurotoxin 1-Methyl-4-Phenylpyridinium-Induced Apoptotic Cell Death
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Han SW, Lee CS, Hwang IH, Han JH, Kim DE
- KMID: 2359443
- J Korean Neurol Assoc.
- 2016 Nov;34(5):324-332.
- doi: 10.17340/jkna.2016.4.6
BACKGROUND: The extract and hemiterpene glycosides of Ilex Rotunda Thunb exert antioxidant and anti-inflammatory effects. The effect of rotundarpene on apoptosis in neuronal cells caused by the 1-methyl-4-phenylpyridinium (MPPâº) has... -
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- Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells
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Kim HJ, Kim J, Kang KS, Lee KT, Yang HO
- KMID: 2170619
- Biomol Ther.
- 2014 Jul;22(4):275-281.
Autophagy is a series of catabolic process mediating the bulk degradation of intracellular proteins and organelles through formation of a double-membrane vesicle, known as an autophagosome, and fusing with lysosome.... -
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- Inhibitory Effect of 3,4,5-Tricaffeoylquinic Acid on Parkinsonian Toxin 1-Methyl-4-phenylpyridinium-induced Apoptosis
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Joo JJ, Kang JH, Han JH, Kim DE, Lee CS
- KMID: 2191157
- J Korean Neurol Assoc.
- 2014 May;32(2):72-81.
BACKGROUND: 1-Methyl-4-phenylpyridinium (MPP+) causes a neuronal cell injury that is similar to the findings observed in Parkinson's disease. Caffeoylquinic acid derivatives have demonstrated anti-oxidant and anti-inflammatory effects. Nevertheless, the effect... -
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- Role of Casein Kinase 2 in Parkinsonian Toxin 1-Methyl-4-phenylpyridinium-induced Cell Death
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Lee SY, Hwang JY, Han JH, Kim DE, Lee CS
- KMID: 2184974
- J Korean Neurol Assoc.
- 2010 Aug;28(3):157-165.
BACKGROUND: Protein casein kinase 2 is involved in signal transduction, cell growth, and apoptosis. However, it has not been elucidated whether parkinsonian toxin 1-methyl-4-phenylpyridinium (MPP+)-induced neuronal cell death is mediated... -
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- Protective Effects of K6PC-5, A Sphingosine Kinase Activator, Against 1-methyl-4-phenylpyridinium-induced Dopaminergic Neuronal Cell Death
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Jang S, Choi SS, Kim SH, Park JS, Jeong HS
- KMID: 2172296
- Chonnam Med J.
- 2008 Dec;44(3):162-168.
- doi: 10.4068/cmj.2008.44.3.162
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metaolite, regulates multiple cellular responses such as Ca2+ signaling, cellular growth and survival, and differentiation. Sphingosine kinase (SphK) is a key enzyme in modulating the... -
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- Protective Effects of Epigallocatechin-3-gallate against 1-methyl-4-phenylpyridinium-induced Dopaminergic Neuronal Cell Death
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Noh HG, Jang S, Park SJ, Kim SH, Jeong HS, Park JS
- KMID: 2274899
- Chonnam Med J.
- 2007 Aug;43(2):73-79.
1-methyl-4-phenylpyridinium (MPP+) is a neurotoxin that selectively inhibits the mitochondrial functions of dopaminergic neurons in the substantia nigra pars compacta. MPP+ administration is accepted as in vivo and in vitro... -
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- Promoting Effect of Hydrogen Peroxide on 1-Methyl-4-phenylpyridinium-induced Mitochondrial Dysfunction and Cell Death in PC12 Cells
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Lee DH, Lee CS
- KMID: 1512942
- Korean J Physiol Pharmacol.
- 2006 Feb;10(1):51-58.
The promoting effect of hydrogen peroxide (H2O2) against the cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) in differentiated PC12 cells was assessed by measuring the effect on the mitochondrial membrane permeability. Treatment of... -
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