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Comparison of Neuropathological Characteristics between Multiple System Atrophy Cerebellar Type and Parkinsonian Type

Kim EJ, Lee S, Jang SH, Lee MJ, Lee JH, Shin JH, Lee YM, Pak K, Jung NY, Yoon JA, Ko JK, Lee JM, Lee K, Hwang C, Ahn JW, Sung S, Choi KU, Huh GY

Background: Multiple system atrophy (MSA) is a sporadic neurodegenerative disease characterized by various combinations of parkinsonism, cerebellar ataxia, autonomic dysfunction and pyramidal signs. Two clinical subtypes are recognized: MSA with...
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Death-associated Protein Kinase 1 Phosphorylates α-Synuclein at Ser129 and Exacerbates Rotenone-induced Toxic Aggregation of α-Synuclein in Dopaminergic SH-SY5Y Cells

Shin WH, Chung KC

  • KMID: 2503981
  • Exp Neurobiol.
  • 2020 Jun;29(3):207-218.
  • doi: 10.5607/en20014
The formation of Lewy bodies (LBs), intracellular filamentous inclusions, is one of the hallmarks of Parkinson's disease (PD). α-Synuclein is the main component of LBs and its abnormal accumulation contributes...
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Diagnostic Criteria for Dementia with Lewy Bodies: Updates and Future Directions

Yamada M, Komatsu J, Nakamura K, Sakai K, Samuraki-Yokohama M, Nakajima K, Yoshita M

The aim of this article is to describe the 2017 revised consensus criteria for the clinical diagnosis of dementia with Lewy bodies (DLB) with future directions for the diagnostic criteria....
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