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Interaction between Intrathecal Gabapentin and Adenosine in the Formalin Test of Rats

Yoon MH, Choi JI, Park HC, Bae HB

Spinal gabapentin and adenosine have been known to display an antinociceptive effect. We evaluated the nature of the interaction between gabapentin and adenosine in formalin-induced nociception at the spinal level....
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The Effect of Intrathecal Gabapentin on Mechanical and Thermal Hyperalgesia in Neuropathic Rats Induced by Spinal Nerve Ligation

Cho HS, Kim MH, Choi DH, Lee JI, Gwak MS, Hahm TS

Gabapentin decreases the level of glutamate and elevates that of garmma-amino-butyric acid in the central nervous system. Gabapentin was shown to have antinociceptive effects in several facilitated pain models. Intrathecal...
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