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Recent advances in chronic lymphocytic leukemia therapy

Uhm J

Chronic lymphocytic leukemia is a genetically heterogeneous disease, and a complex set of genetic alterations is associated with its pathogenesis. CLL is the most common leukemia in the western countries,...
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Treatment after failure of frontline therapy of chronic myeloid leukemia in chronic phase including allogeneic hematopoietic stem cell transplantation

Uhm J

The treatment outcomes of chronic myeloid leukemia in chronic phase (CML-CP) have dramatically improved with comparable life-expectancy to average of general population in tyrosine kinase inhibitor (TKI) era. However, less...
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Differences in anticoagulation strategy and outcome in atrial fibrillation patients with chronic kidney disease: a CODE‑AF registry study

Choi Y, Uhm J, Kim T, Choi Y, Uhm J, Cha M, Kim T, Lee J, Park J, Park J, Kang K, Shim J, Kim J, Park H, Choi E, Kim J, Kim C, Lee Y, Joung B

Purpose: Dose reduction of non-vitamin K antagonist oral anticoagulants (NOACs) is indicated in patients with atrial fibrillation (AF) with renal impairment. This study investigated anticoagulation patterns and outcomes in patients...
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Patient Blood Management: An Internist's Perspective

Uhm J

Patient blood management (PBM) is an evidence-based, patient-focused approach to optimize the management of patient and blood transfusion. While PBM is relatively well established in perioperative care, it is not...
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Clinical and genetic relationships between the QTc interval and risk of a stroke among atrial fibrillation patients undergoing catheter ablation

Hong M, Chun K, Hwang I, Yu H, Kim T, Uhm J, Joung B, Lee M, Pak H

Background and objectives: A prolonged QTc interval is associated with an increased risk of a stroke or atrial fibrillation (AF). However, its direct causal relationship with AF associated a stroke...
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Accuracy and clinical feasibility of 3D‑myocardial thickness map measured by cardiac computed tomogram

Kwon O, Lee J, Lim S, Park J, Han H, Yang S, Hwang I, Yu H, Kim T, Uhm J, Joung B, Lee M, Pak H

Background: Although myocardial thickness is an important variable for therapeutic catheter ablation of cardiac arrhythmias, quantification of wall thickness has been overlooked. We developed a software (AMBER) that measures 3D-myocardial...
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Real-world management of chronic myeloid leukemia in South Korea: the TARGET survey

Uhm J, Kim KH, Lee H, Kim H, Cassandra S, Joo I, Jung CW

Background: The global TARGET survey examined real-world management of chronic myeloid leukemia (CML) compared with international guideline recommendations. This report focused on the responses of physicians from South Korea compared...
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Multiple atrial premature contractions predict stroke recurrence in patients with cryptogenic stroke and concomitant non‑sustained atrial tachycardia

Cha J, Chung H, Uhm J, Joung B, Pak H, Lee M, Kim J

Background and objectives: Atrial fibrillation is a known risk factor for cryptogenic stroke and therefore requires early detection and prompt management. We investigated predictors of stroke recurrence in patients with...
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In silico screening method for non‑responders to cardiac resynchronization therapy in patients with heart failure: a pilot study

Hwang M, Uhm J, Park M, Shim E, Lee C, Oh J, Yu H, Kim T, Joung B, Pak H, Kang S, Lee M

Background: Cardiac resynchronization therapy (CRT) is an effective treatment option for patients with heart failure (HF) and left ventricular (LV) dyssynchrony. However, the problem of some patients not responding to CRT...
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Characteristics of symptom burden in atrial fibrillation with concomitant heart failure

Heo R, Cha M, Kim T, Lee J, Park J, Park H, Kang K, Shim J, Uhm J, Kim J, Kim J, Kim C, Lee Y, Choi E, Joung B, Park J

Background:Symptom burden is an important factor in determining the treatment of atrial fibrillation (AF). AF is frequently accompanied by heart failure (HF). This study investigated the characteristics of AF symptoms...
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