- Introduction to dynamical systems analysis in quantitative systems pharmacology: basic concepts and applications
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Chae D
- KMID: 2512005
- Transl Clin Pharmacol.
- 2020 Sep;28(3):109-125.
- doi: 10.12793/tcp.2020.28.e12
Quantitative systems pharmacology (QSP) can be regarded as a hybrid of pharmacometrics and systems biology. Here, we introduce the basic concepts related to dynamical systems theory that are fundamental to... -
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- Predicting human pharmacokinetics from preclinical data: absorption
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Yim DS, Choi S, Bae SH
- KMID: 2512004
- Transl Clin Pharmacol.
- 2020 Sep;28(3):126-135.
- doi: 10.12793/tcp.2020.28.e14
Predicting the rate and extent of oral absorption of drugs in humans has been a challenging task for new drug researchers. This tutorial reviews in vivo and PBPK methods reported... -
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- Pharmacodynamic evaluation of YH4808 for Helicobacter pylori eradication in healthy subjects
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Park H, Kim CO, Kim M, Lim Y, Lee WY, Yoon S, Park MS
- KMID: 2512003
- Transl Clin Pharmacol.
- 2020 Sep;28(3):136-146.
- doi: 10.12793/tcp.2020.28.e16
YH4808 is a novel selective potassium-competitive acid blocker demonstrated to be safe and to have inhibitory effects against gastric acid secretion in previous studies. A randomized, open-label, multiple-dose, 3-treatment, 1-period,... -
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- Bioequivalence of the pharmacokinetics between tofacitinib aspartate and tofacitinib citrate in healthy subjects
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Shin W, Yang AY, Yun H, Cho DY, Park KH, Shin H, Kim A
- KMID: 2512001
- Transl Clin Pharmacol.
- 2020 Sep;28(3):160-167.
- doi: 10.12793/tcp.2020.28.e13
Tofacitinib is an oral disease-modifying anti-rheumatic drug to selectively inhibit Janus kinases. Tofacitinib is a representative small molecule inhibitor that is used to treat many diseases including rheumatoid arthritis and... -
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- Qualification and application of liquid chromatography-quadrupole time-offlight mass spectrometric method for the determination of carisbamate in rat plasma and prediction of its human pharmacokinetics using physiologically based pharmacokinetic modeling
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Lee Bi, Lim Jh, Park MH, Shin SH, Byeon JJ, Choi Jm, Park Sj, Park Mj, Park Y, Shin YG
- KMID: 2512002
- Transl Clin Pharmacol.
- 2020 Sep;28(3):147-159.
- doi: 10.12793/tcp.2020.28.e15
Carisbamate is an antiepileptic drug and it also has broad neuroprotective activity and anticonvulsant reaction. In this study, a liquid chromatography-quadrupole time-of-flight mass spectrometric (LC-qTOF-MS) method was developed and applied... -
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