- Angiopoietin-Like Protein 2 Induces Synovial Inflammation in the Facet Joint Leading to Degenerative Changes via Interleukin-6 Secretion
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Sugimoto K, Nakamura T, Tokunaga T, Uehara Y, Okada T, Taniwaki T, Fujimoto T, Oike Y, Nakamura E
- KMID: 2449790
- Asian Spine J.
- 2019 Jun;13(3):368-376.
- doi: 10.31616/asj.2018.0178
STUDY DESIGN: Experimental human study. PURPOSE: To determine whether angiopoietin-like protein 2 (ANGPTL2) is highly expressed in the hyperplastic facet joint (FJ) synovium and whether it activates interleukin-6 (IL-6) secretion in... -
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- Regulation of Cartilage Development and Diseases by Transcription Factors
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Nishimura , Hata K, Takahata Y, Murakami T, Nakamura E, Yagi H
- KMID: 2415952
- J Bone Metab.
- 2017 Aug;24(3):147-153.
- doi: 10.11005/jbm.2017.24.3.147
Genetic studies and molecular cloning approaches have been successfully used to identify several transcription factors that regulate the numerous stages of cartilage development. Sex-determining region Y (SRY)-box 9 (Sox9) is... -
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- Chronic obstructive pulmonary disease severity in middle-aged and older men with steoporosis associates with decreased bone formation
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Tsukamoto M, Mori T, Nakamura E, Okada Y, Fukuda H, Yamanaka Y, Sabanai K, Wang KY, Hanagiri T, Kuboi S, Yatera K, Sakai A
- KMID: 2509973
- Osteoporos Sarcopenia.
- 2020 Dec;6(4):179-187.
- doi: 10.1016/j.afos.2020.11.003
Objectives Chronic obstructive pulmonary disease (COPD) is a risk factor for osteoporosis. Nevertheless, much remains unclear regarding the bone metabolism dynamics associated with COPD. The present study focuses on the associations... -
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