- Diet, microbiota, and inflammatory bowel disease: lessons from Japanese foods
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Kanai T, Matsuoka K, Naganuma M, Hayashi A, Hisamatsu
- KMID: 2070102
- Korean J Intern Med.
- 2014 Jul;29(4):409-415.
The incidence and prevalence of inflammatory bowel diseases (IBDs) including ulcerative colitis and Crohn disease are rapidly increasing in Western countries and in developed Asian countries. Although biologic agents targeting... -
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- Current new challenges in the management of ulcerative colitis
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Fukuda T, Naganuma M, Kanai T
- KMID: 2438441
- Intest Res.
- 2019 Jan;17(1):36-44.
- doi: 10.5217/ir.2018.00126
Ulcerative colitis (UC) is a chronic inflammatory condition of the gastrointestinal tract. Although the cause of UC is postulated to be multifactorial in nature, including genetic predisposition, epithelial barrier defects,... -
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- Evaluation of a new method, “non-injection resection using bipolar soft coagulation mode (NIRBS)”, for colonic adenomatous lesions
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Tokuhara M, Shimatani M, Tominaga K, Nakahira H, Ohtsu T, Kouda K, Naganuma M
- KMID: 2546141
- Clin Endosc.
- 2023 Sep;56(5):623-632.
- doi: 10.5946/ce.2022.200
Background/Aims: Endoscopic resection of all colorectal adenomatous lesions with a low complication rate, simplicity, and negative residuals is challenging. Hence, we developed a new method called “non-injection resection using bipolar... -
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- Recent trends in diagnostic techniques for inflammatory bowel disease
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Naganuma M, Hosoe N, Kanai T, Ogata H
- KMID: 2160699
- Korean J Intern Med.
- 2015 May;30(3):271-278.
- doi: 10.3904/kjim.2015.30.3.271
Although ileocolonoscopy is the gold standard for diagnosis of inflammatory bowel disease and is useful for assessing the disease severity in the colon and terminal ileum, several alternative diagnostic techniques... -
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- Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis
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Nanki K, Mizuno S, Matsuoka K, Ono K, Sugimoto S, Kiyohara H, Arai M, Nakashima , Takeshita , Saigusa K, Senoh M, Fukuda T, Naganuma M, Kato H, Suda W, Hattori M, Kanai T
- KMID: 2402658
- Intest Res.
- 2018 Jan;16(1):142-146.
- doi: 10.5217/ir.2018.16.1.142
Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrent Clostridium difficile infection (CDI). FMT has also been reported as a... -
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- Effect of elemental diet combined with infliximab dose escalation in patients with Crohn's disease with loss of response to infliximab: CERISIER trial
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Hisamatsu , Kunisaki R, Nakamura S, Tsujikawa , Hirai F, Nakase H, Watanabe K, Yokoyama K, Nagahori M, Kanai T, Naganuma M, Michimae H, Andoh A, Yamada A, Yokoyama T, Kamata N, Tanaka S, Suzuki Y, Hibi T, Watanabe M, CERISIER Trial group
- KMID: 2417663
- Intest Res.
- 2018 Jul;16(3):494-498.
- doi: 10.5217/ir.2018.16.3.494
No abstract available. -
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- 5-Aminosalicylic acid aggravates colitis mimicking exacerbation of ulcerative colitis
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Miyoshi J, Matsuoka K, Yoshida A, Naganuma M, Hisamatsu , Yajima T, Inoue N, Okamoto S, Iwao Y, Ogata H, Ueno F, Hibi T, Kanai T
- KMID: 2434166
- Intest Res.
- 2018 Oct;16(4):635-640.
- doi: 10.5217/ir.2018.00015
Ulcerative colitis (UC) is one of the major clinical phenotypes of inflammatory bowel diseases. Although 5-aminosalicylic acid (5-ASA) is widely used for UC and its efficacy and safety have been... -
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- Effects of the Oral Administration of Mosapride Citrate on Capsule Endoscopy Completion Rate
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Ida Y, Hosoe N, Imaeda H, Bessho R, Ichikawa R, Naganuma M, Kanai T, Hibi T, Ogata H
- KMID: 2053496
- Gut Liver.
- 2012 Jul;6(3):339-343.
BACKGROUND/AIMS: In capsule endoscopy (CE), the capsule does not always reach the cecum within its battery life, which may reduce its diagnostic yield. We evaluated the effect of mosapride citrate,... -
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- Predictive factors for achievement of mucosal healing by budesonide 2-mg foam in ulcerative colitis: a pooled analysis of data from two clinical trials
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Hibi T, Naganuma M, Oda E, Yamada Y, Chujoh Y, Yoshihara , Watanabe M
- KMID: 2501367
- Intest Res.
- 2020 Jan;18(1):56-68.
- doi: 10.5217/ir.2019.00064
Background/Aims: Mucosal healing (MH) of distal lesions in ulcerative colitis (UC) has recently been confirmed with budesonide 2-mg foam (BF) treatment in 2 clinical trials; however, few studies have investigated... -
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- 5-Aminosalicylic acid intolerance is associated with a risk of adverse clinical outcomes and dysbiosis in patients with ulcerative colitis
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Mizuno S, Ono K, Mikami Y, Naganuma M, Fukuda T, Minami K, Masaoka T, Terada S, Yoshida T, Saigusa K, Hirahara N, Miyata H, Suda W, Hattori M, Kanai T
- KMID: 2501368
- Intest Res.
- 2020 Jan;18(1):69-78.
- doi: 10.5217/ir.2019.00084
Background/Aims: 5-Aminosalicylic acid (ASA) causes intolerance reactions in some patients. This study was performed to examine the prognosis of patients with ulcerative colitis (UC) and 5-ASA intolerance, and to evaluate... -
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- Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn’s Disease: A Propensity Score-Matched Study
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Takabayashi K, Hosoe N, Kato M, Hayash Y, Miyanaga R, Nanki K, Fukuhara K, Shinta Mizuno YM, Sujino T, Mutaguchi M, Naganuma M, Yahagi N, Ogata H, Kanai T, Mizuno S
- KMID: 2506436
- Gut Liver.
- 2020 Sep;14(5):619-625.
- doi: 10.5009/gnl19228
Background/Aims: The evaluation of small bowel lesions of Crohn’s disease (CD) using balloon-assisted enteroscopy (BAE) is crucial because mucosal healing is associated with a good prognosis. However, BAE procedures are... -
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- Long-term safety and efficacy of adalimumab for intestinal Behçet's disease in the open label study following a phase 3 clinical trial
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Inoue N, Kobayashi , Naganuma M, Hirai F, Ozawa M, Arikan D, Huang B, Robinson A, Thakkar RB, Hibi T
- KMID: 2382384
- Intest Res.
- 2017 Jul;15(3):395-401.
- doi: 10.5217/ir.2017.15.3.395
BACKGROUND/AIMS: Intestinal Behçet's disease (BD) is an immune-mediated inflammatory disorder. We followed up the patients and evaluated safety profile and effectiveness of adalimumab for the treatment of intestinal BD through... -
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- Single fecal microbiota transplantation failed to change intestinal microbiota and had limited effectiveness against ulcerative colitis in Japanese patients
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Mizuno S, Nanki K, Matsuoka K, Saigusa K, Ono K, Arai M, Sugimoto S, Kiyohara H, Nakashima , Takeshita , Naganuma M, Suda W, Hattori M, Kanai T
- KMID: 2368487
- Intest Res.
- 2017 Jan;15(1):68-74.
- doi: 10.5217/ir.2017.15.1.68
BACKGROUND/AIMS: Recent developments in analytical techniques including next-generation sequencing have clarified the correlation between intestinal microbiota and inflammatory bowel disease. Fecal microbiota transplantation (FMT) for patients with ulcerative colitis (UC)... -
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- β-(1,3)-Glucan derived from Candida albicans induces inflammatory cytokines from macrophages and lamina propria mononuclear cells derived from patients with Crohn's disease
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Mori K, Naganuma M, Mizuno S, Suzuki H, Kitazume M, Shimamura , Chiba S, Sugita A, Matsuoka K, Hisamatsu , Kanai T
- KMID: 2417650
- Intest Res.
- 2018 Jul;16(3):384-392.
- doi: 10.5217/ir.2018.16.3.384
BACKGROUND/AIMS: Recent research has highlighted the importance of interactions between commensal fungi and intestinal inflammation. However, there are few studies investigating whether commensal fungi contribute to inflammation in patients with... -
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- Pregnancy outcome in women with inflammatory bowel disease treated with anti-tumor necrosis factor and/or thiopurine therapy: a multicenter study from Japan
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Komoto S, Motoya S, Nishiwaki , Matsui T, Kunisaki R, Matsuoka K, Yoshimura , Kagaya T, Naganuma M, Hida N, Watanabe M, Hibi T, Suzuki Y, Miura S, Hokari R, Japanese study group for pregnant women with IBD
- KMID: 2425286
- Intest Res.
- 2016 Apr;14(2):139-145.
- doi: 10.5217/ir.2016.14.2.139
BACKGROUND/AIMS: Anti-tumor necrosis factor drugs (anti-TNF) and thiopurines are important treatment options in patients with inflammatory bowel disease (IBD), including during pregnancy. However, there are limited data on the benefit/risk... -
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