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Efffects of Fluoxetine on ATP-induced Calcium Signaling in PC12 Cells

Lee YM, Kim HJ, Hong SH, Kim MJ, Min DS, Rhie DJ, Kim MS, Jo YH, Hahn SJ, Yoon SH

  • KMID: 1517038
  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):57-63.
Fluoxetine, a widely used anti-depressant compound, has several additional effects, including blockade of voltage-gated ion channels. We examined whether fluoxetine affects ATP-induced calcium signaling in PC12 cells by using fura-2-based...
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Phospholipase D is involved in oxidative stress-induced migration of vascular smooth muscle cells via tyrosine phosphorylation and protein kinase C

Kim J, Min G, Bae YS, Min DS

  • KMID: 1380203
  • Exp Mol Med.
  • 2004 Apr;36(2):103-109.
Oxidative stress has been implicated in mediation of vascular disorders. In the presence of vanadate, H2O2 induced tyrosine phosphorylation of PLD1, protein kinase C-a (PKC-a), and other unidentified proteins in...
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Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells

Kang DW, Min G, Park DY, Hong KW, Min DS

Rebamipide a gastroprotective drug, is clinically used for the treatment of gastric ulcers and gastritis, but its actions on gastric cancer are not clearly understood. Phospholipase D (PLD) is overexpressed...
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Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells

Ahn BH, Min G, Bae YS, Bae YS, Min DS

  • KMID: 1105277
  • Exp Mol Med.
  • 2006 Feb;38(1):55-62.
Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells. Moreover, CKII-selective inhibitor, emodin and...
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Comparative Analysis of Phospholipase D2 Localization in the Pancreatic Islet of Rat and Guinea Pig

Ryu GR, Kim MJ, Song CH, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH

  • KMID: 2285289
  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):211-216.
To examine the localization pattern of phospholipase D2 (PLD2) in the pancreatic islet (the islet of Langerhans) depending on species, we conducted a morphological experiment in the rat and guinea...
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Altered Secretory Pattern of Pancreatic Enzymes and Gastrointestinal Hormones in Streptozotocin-induced Diabetic Rats

Kim MJ, Ryu GR, Yi SY, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH

  • KMID: 1615198
  • Korean J Physiol Pharmacol.
  • 2002 Dec;6(6):311-317.
This study was performed to investigate the pancreatic exocrine dysfunction in streptozotocin- induced diabetic rats. Changes in pancreatic enzymes secretion and in pancreatic enzymes content were observed. The output and...
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The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus

Jang YH, Min DS

  • KMID: 1506220
  • Exp Mol Med.
  • 2012 Oct;44(10):571-577.
Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. PLD is localized in most cellular organelles, where it is likely to play different...
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Immunohistochemical Localization of Phospholipase D1 in Developing Rat Forebrain

Choi JS, Min DS, Chung JW, Chun MH, Lee MY

  • KMID: 1559034
  • Korean J Anat.
  • 2001 Aug;34(4):427-434.
Phospholipase D (PLD), one of the intracellular signal transduction enzymes, may play an important role in developing brain. However, the developmental regulation of PLD protein has not been determined. In...
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The expression and cellular localization of phospholipase D isozymes in the developing mouse testis

Kim S, Kim H, Lee Y, Hyun JW, Lee YH, Shin MK, Min DS, Shin T

To examine the involvement of phospholipase D (PLD)isozymes in postnatal testis development, the expression ofPLD1 and PLD2 was examined in the mouse testis atpostnatal weeks 1, 2, 4, and 8...
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Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase

Jang MJ, Lee MJ, Park HY, Bae YS, Min DS, Ryu SH, Kwak JY

  • KMID: 1380212
  • Exp Mol Med.
  • 2004 Apr;36(2):172-178.
Agents that elevate cellular cAMP are known to inhibit the activation of phospholipase D (PLD). We investigated whether PLD can be phosphorylated by cAMP-dependent protein kinase (PKA) and PKA-mediated phosphorylation...
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The p38 mitogen-activated protein kinase is involved in stress-induced phospholipase D activation in vascular smooth muscle cells

Min DS, Shin EY, Kim EG

  • KMID: 1093596
  • Exp Mol Med.
  • 2002 Mar;34(1):38-46.
Oxidative stress has been implicated in mediation of vascular disorders. Earlier study showed that the exposure of vascular smooth muscle cells (VSMC) to pervanadate (hydrogen peroxide plus orthovanadate) resulted in...
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Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells

Hwang WC, Kim MK, Song JH, Choi KY, Min DS

Autophagy is a conserved lysosomal self-digestion process used for the breakdown of long-lived proteins and damaged organelles, and it is associated with a number of pathological processes, including cancer. Phospholipase...
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Electrophysiological and Morphological Classification of Inhibitory Interneurons in Layer II/III of the Rat Visual Cortex

Rhie DJ, Kang HY, Ryu GR, Kim MJ, Yoon SH, Hahn SJ, Min DS, Jo YH, Kim MS

  • KMID: 1607516
  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):317-323.
Interneuron diversity is one of the key factors to hinder understanding the mechanism of cortical neural network functions even with their important roles. We characterized inhibitory interneurons in layer II/III...
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Effect of Transurethral Resection of the Prostate Based on the Degree of Obstruction Seen in Urodynamic Study

Min DS, Cho HJ, Kang JY, Yoo TK, Cho JM

  • KMID: 2315940
  • Korean J Urol.
  • 2013 Dec;54(12):840-845.
PURPOSE: We retrospectively investigated the effect of transurethral resection of the prostate (TURP) on the basis of the degree of obstruction seen in preoperative urodynamic study in patients with benign...
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Altered Cholecystokinin-induced Calcium Signal in Streptozotocin-induced Diabetic Rat Pancreatic Acini

Kim MJ, Ryu GR, Sung JH, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS

  • KMID: 1066043
  • Korean J Gastroenterol.
  • 2003 Dec;42(6):519-526.
BACKGROUND/AIMS: Pancreatic acini of streptozotocin (STZ)-induced diabetic rats release amylase less than normal acini on cholecystokinin (CCK) stimulation. Pancreatic enzyme secretion has been closely related to the intracellular calcium...
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Efficacy of Alfuzosin After Shock Wave Lithotripsy for the Treatment of Ureteral Calculi

Cho HJ, Shin SC, Seo DY, Min DS, Cho JM, Kang JY, Yoo TK

  • KMID: 2316073
  • Korean J Urol.
  • 2013 Feb;54(2):106-110.
PURPOSE: We evaluated the efficacy of alfuzosin for the treatment of ureteral calculi less than 10 mm in diameter after extracorporeal shock wave lithotripsy (ESWL). MATERIALS AND METHODS: A randomized, single-blind...
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Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells

Kang DW, Lee JY, Oh DH, Park SY, Woo TM, Kim MK, Park MH, Jang YH, Min DS

In spite of the importance of phospholipase D (PLD) in cell proliferation and tumorigenesis, little is known about the molecules regulating PLD expression. Thus, identification of small molecules inhibiting PLD...
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Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/beta-catenin pathway activation

Hwang JH, Cha PH, Han G, Bach TT, Min DS, Choi KY

The Wnt/beta-catenin pathway has a role in osteoblast differentiation and bone formation. We screened 100 plant extracts and identified an extract from Euodia sutchuenensis Dode (ESD) leaf and young branch...
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Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid

Han S, Huh J, Kim W, Jeong S, Min DS, Jung Y

Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Therefore, PLD is...
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The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5

Park MH, Choi KY, Min DS

Endocytosis is differentially regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) and phospholipase D (PLD). However, the relationship between HIF-1alpha and PLD in endocytosis is unknown. HIF-1alpha is degraded through the prolyl hydroxylase...
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