- The ‘R’ principles in laboratory animal experiments
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Lee KH, Lee DW, Kang BC
- KMID: 2510416
- Lab Anim Res.
- 2020 Dec;36(4):363-365.
- doi: 10.1186/s42826-020-00078-6
Since the Three Rs of replacement, reduction and refinement was proposed by Russel and Birch in 1959, researchers have a moral duty to minimize harm to animals. Even though animal... -
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- Correction to: Influence of three BALB/c substrain backgrounds on the skin tumor induction efficacy to DMBA and TPA cotreatment
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Kang MJ, Gong JE, Kim JE, Choi HJ, Bae SJ, Choi YJ, Lee SJ, Seo MS, Kim KS, Jung YS, Cho JY, Lim Y, Hwang DY
- KMID: 2510417
- Lab Anim Res.
- 2020 Dec;36(4):366-367.
- doi: 10.1186/s42826-020-00067-9
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- Refining drug administration in a murine model of acute infection with Trypanosoma cruzi
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Nicolás Gulin JE, Bisio M, García-Bournissen F
- KMID: 2510415
- Lab Anim Res.
- 2020 Dec;36(4):356-362.
- doi: 10.1186/s42826-020-00071-z
Background: In animal research, “refinement” refers to modifications of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress. Evaluation of drug efficacy in mice... -
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- Comparative analysis of immune related genes between domestic pig and germ-free minipig
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Lee JY, Kim SE, Lee HT, Hwang JH
- KMID: 2510413
- Lab Anim Res.
- 2020 Dec;36(4):345-350.
- doi: 10.1186/s42826-020-00077-7
Recently, minipig has been considered as an animal model that is appropriate for human disease model to study toxicology, pharmacology, and xenotransplantation. Nevertheless, minipigs are bred in various environment according... -
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- Unexpected effects of ivermectin and selamectin on inducible Cre ER activity in mice
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Kropp PA, Rushing GV, Brockman AA, Yu ENZ, Ihrie RA, Gannon M
- KMID: 2510414
- Lab Anim Res.
- 2020 Dec;36(4):351-355.
- doi: 10.1186/s42826-020-00069-7
Background: Anti-parasitics are frequently used in research animal facilities to treat a multitude of common infections, with pinworms and fur mites being amongst the most common. Ivermectin and selamectin are... -
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- A comparative study of the phenotype with kainic acid-induced seizure in DBA/2 mice from three different sources
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Kang KK, Kim YI, Seo MS, Sung SE, Choi JH, Lee S, Jung YS, Cho JY, Hwang DY, Park SJ, Kim KS
- KMID: 2510408
- Lab Anim Res.
- 2020 Dec;36(4):303-309.
- doi: 10.1186/s42826-020-00072-y
The kainic acid-induced seizure mouse model is widely used in epilepsy research. In this study, we applied kainic acid to the subcutaneous injections of three different sources of DBA/2 mice... -
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- Extensive variability in the composition of immune infiltrate in different mouse models of cancer
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Niemi V, Gaskarth D, Kemp RA
- KMID: 2510412
- Lab Anim Res.
- 2020 Dec;36(4):335-344.
- doi: 10.1186/s42826-020-00075-9
Mouse models are invaluable tools for cancer immunology research. However, there are differences in the immune response to the tumour depending on the model used, and these differences are not... -
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- Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra
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Lee HA, Kim JY, Kim J, Nam B, Kim O
- KMID: 2510409
- Lab Anim Res.
- 2020 Dec;36(4):310-317.
- doi: 10.1186/s42826-020-00073-x
The effect of standard therapeutic strategies on Helicobacter pylori infection is diminished over time owing to the emergence of drug resistant strains. In this study, we would like to confirm... -
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- Impaired liver regeneration and lipid homeostasis in CCl4 treated WDR13 deficient mice
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Mishra AP, Siva AB, Gurunathan C, Komala Y, Lakshmi BJ
- KMID: 2510410
- Lab Anim Res.
- 2020 Dec;36(4):318-327.
- doi: 10.1186/s42826-020-00076-8
WDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic β-cell proliferation,... -
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- Evaluation of skin phototoxicity of transdermally administered pharmaceuticals in Sprague-Dawley rats
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Youn NH, Kim EJ, Yi JS, Kim JH, Cho YJ, Nam KT, Park KS, Lee JK
- KMID: 2510411
- Lab Anim Res.
- 2020 Dec;36(4):328-334.
- doi: 10.1186/s42826-020-00074-w
Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test... -
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- Pathogenicity of severe fever with thrombocytopenia syndrome virus in mice regulated in type I interferon signaling Severe fever with thrombocytopenia and type I interferon
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Park SC, Park JY, Choi JY, Lee SG, Eo SK, Oem JK, Tark DS, You M, Yu DH, Chae JS, Kim B
- KMID: 2510407
- Lab Anim Res.
- 2020 Dec;36(4):293-302.
- doi: 10.1186/s42826-020-00070-0
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic disease, which causes high fever, thrombocytopenia, and death in humans and animals in East Asian countries. The pathogenicity of SFTS... -
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