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Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases

Ka J, Jin SW

Dyslipidemia related diseases such as hyperlipidemia and atherosclerosis are the leading cause of death in humans. While cellular and molecular basis on the pathophysiology of dyslipidemia has been extensively investigated...
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HDL-C and Cardiovascular Risk: You Don't Need to Worry about Extremely High HDL-C Levels

Cho YK, Jung CH

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Impact of Obesity-Related Inflammation on Cardiac Metabolism and Function

Larsen TS, Jansen KM

This review focuses on the role of adipose tissue in obese individuals in the development of metabolic diseases, and their consequences for metabolic and functional derangements in the heart. The...
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Inborn Errors of Mitochondrial Fatty Acid Oxidation: Overview from a Clinical Perspective

Yoo HW

Mitochondrial fatty acid β-oxidation (mFAO), which is the major pathway for the degradation of fatty acids and is critical for maintaining energy homeostasis in the human body, consists of carnitine...
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Rapid Way to Generate Mouse Models for In Vivo Studies of the Endothelium

Lee H

A single layer of squamous endothelial cells (ECs), the endothelium, regulates the flow of substance and fluid into and out of a tissue. The endothelium is also involved in vasculogenesis,...
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Zingerone Attenuates Pi-induced Vascular Calcification via AMPK-mediated TIMP4 Expression

Lim YJ, Min HY, Jang WG

Objective: Vascular calcification requires the differentiation of vascular smooth muscle cells (VSMCs) into osteoblast-like cells. This phenomenon can be enhanced by inflammation and oxidative stress. Zingerone is one of the...
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Differential Angiogenic Responses of Human Endothelial Colony-Forming Cells to Different Molecular Subtypes of Breast Cancer Cells

Lee H, Kang KT

Objective: Triple negative breast cancer (TNBC) is one subtype of breast cancer. It is characterized by lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Compared...
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Modulation of Vascular Smooth Muscle Cell Phenotype by High Mobility Group AT-Hook 1

Jung Y, Lee HS, Ha JM, Jin SY, Kum HJ, Vafaeinik F, Ha HK, Song SH, Kim CD, Bae SS

Objective: The purpose of this study is to examine the effect of high mobility group AT-hook 1 (HMGA1) on the phenotyptic change of vascular smooth muscle cells (VSMCs). Methods: Gene silencing...
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Hypertriglyceridemia Is an Independent Risk Factor for Cardiovascular Diseases in Korean Adults Aged 30–49 Years: a Nationwide Population-Based Study

Koo BK, Park S, Han KD, Moon MK

Objective: This study was conducted to estimate the incidence of cardiovascular disease (CVD) independently from low-density lipoprotein (LDL) cholesterol according to triglyceride (TG) levels in young adults. Methods: Subjects aged 30–49...
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High-Density Lipoprotein Cholesterol and the Risk of Myocardial Infarction, Stroke, and Cause-Specific Mortality: a Nationwide Cohort Study in Korea

Yang Y, Han K, Park SH, Kim MK, Yoon KH, Lee SH

Objective: We aimed to investigate the relationship between high-density lipoprotein cholesterol (HDL-C) level and the risk of myocardial infarction (MI), stroke, and causespecific mortality. Methods: Using the Korean National Health Insurance...
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