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Potential Role of Sirtuin as a Therapeutic Target for Neurodegenerative Diseases

Han SH

The sirtuins (SIRTs) are protein-modifying enzymes that are distributed ubiquitously in all organisms. SIRT1 is a mammalian homologue of yeast nicotinamide-adenine-dinucleotide-dependent deacetylase silent information regulator 2 (known as Sir2), which...
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Anti-Ri-Antibody-Associated Paraneoplastic Syndrome in a Man with Breast Cancer Showing a Reversible Pontine Lesion on MRI

Kim H, Lim Y, Kim KK

BACKGROUND: Paraneoplastic neurological disorders associated with anti-Ri-antibodies, which are typically present with opsoclonus-myoclonus-ataxia. Most cases with anti-Ri-antibodyassociated paraneoplastic syndrome due to breast cancer occur in women - its occurrence in...
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Secondary Amyloidosis Associated with Multiple Sclerosis

Kang SJ, Yi JH, Hong HS, Jang SH, Park MH, Kim HJ, Lee KY, Lee YJ, Han SW, Koh SH

BACKGROUND: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Secondary amyloidosis can occur as a complication of chronic systemic inflammatory and infectious diseases. Until now there...
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Multimodal MRI for Ischemic Stroke: From Acute Therapy to Preventive Strategies

Bang OY

BACKGROUND AND PURPOSE: Conventional therapies for ischemic stroke include thrombolytic therapy, prevention of inappropriate coagulation and thrombosis, and surgery to repair vascular abnormalities. Over 10 years have passed since the...
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Relationships between 24-Hour Blood Pressures, Subcortical Ischemic Lesions, and Cognitive Impairment

Kim JE, Shin JS, Jeong JH, Choi KG, Park KD, Kim S

BACKGROUND AND PURPOSE: The most important treatment for subcortical vascular dementia (SVaD) is controlling the blood pressure (BP). However, the few studies that have investigated the relationships between diurnal BP...
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Common Carotid Artery Agenesis: Duplex Ultrasonographic Findings

Yim SJ, Ryu JH, Baik JS, Kim JY, Park JH, Han SW

BACKGROUND: Agenesis of the common carotid artery (CCA) resulting in separation of the origin of the external carotid artery (ECA) and internal carotid artery (ICA) from the aortic arch is...
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Cognitive Impairment in Parkinson's Disease without Dementia: Subtypes and Influences of Age

Kim JW, Cheon SM, Park MJ, Kim S, Jo HY

BACKGROUND AND PURPOSE: Cognitive impairments are common in Parkinson's disease (PD), although the severity of these impairments does not significantly impair the patient's daily activities. The aim of this study...
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Levels of Soluble Receptor for Advanced Glycation End Products in Acute Ischemic Stroke without a Source of Cardioembolism

Park HY, Yun KH, Park DS

BACKGROUND AND PURPOSE: Low levels of soluble receptor for advanced glycation end products (sRAGE) are associated with three conventional vascular risk factors (3Fs: diabetes, hypertension, and hypercholesterolemia), nondiabetic coronary artery...
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