- Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy
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Tomasetti , Lee W, Santarelli L, Neuzil J
- KMID: 2367531
- Exp Mol Med.
- 2017 Jan;49(1):e285.
- doi: 10.1038/emm.2016.153
Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell–cell communication by transferring nucleic acids and proteins... -
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- Bioinformatic identification of prognostic signature defined by copy number alteration and expression of CCNE1 in non-muscle invasive bladder cancer
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Song BN, Kim SK, Chu IS
- KMID: 2367528
- Exp Mol Med.
- 2017 Jan;49(1):e282.
- doi: 10.1038/emm.2016.120
Non-muscle invasive bladder cancer (NMIBC) patients frequently fail to respond to treatment and experience disease progression because of their clinical and biological diversity. In this study, we identify a prognostic... -
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- Paclitaxel-resistant cancer cell-derived secretomes elicit ABCB1-associated docetaxel cross-resistance and escape from apoptosis through FOXO3a-driven glycolytic regulation
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Aldonza MB, Hong JY, Lee SK
- KMID: 2367532
- Exp Mol Med.
- 2017 Jan;49(1):e286.
- doi: 10.1038/emm.2016.131
Chemotherapy-induced cancer cell secretomes promote resistance due, in part, to a predominant glycolytic energy metabolism, which drives aggressive cancer cell proliferation. However, the characterization of these secretomes and the molecular... -
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- Epigenetic regulation and chromatin remodeling in learning and memory
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Kim S, Kaang BK
- KMID: 2367527
- Exp Mol Med.
- 2017 Jan;49(1):e281.
- doi: 10.1038/emm.2016.140
Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in the field of neuroscience. Memory formation and maintenance are tightly controlled complex processes. Among the... -
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- Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis
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Agrawal V, Kim DY, Kwon YG
- KMID: 2367535
- Exp Mol Med.
- 2017 Jan;49(1):e289.
- doi: 10.1038/emm.2016.139
Tumor growth is governed by the coordinated action of various types of cells that are present in the tumor environment. Fibroblasts, which constitute a major fraction of the stroma, participate... -
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- Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro
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Shin SK, Kim JH, Lee JH, Son YH, Lee MW, Kim HJ, Noh SA, Kim KP, Kim IG, Lee MJ
- KMID: 2367533
- Exp Mol Med.
- 2017 Jan;49(1):e287.
- doi: 10.1038/emm.2016.133
Proteasomes are the primary degradation machinery for oxidatively damaged proteins that compose a class of misfolded protein substrates. Cellular levels of reactive oxygen species increase with age and this cellular... -
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- hMSCs suppress neutrophil-dominant airway inflammation in a murine model of asthma
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Hong GH, Kwon HS, Lee KY, Ha EH, Moon KA, Kim SW, Oh W, Kim TB, Moon HB, Cho YS
- KMID: 2367534
- Exp Mol Med.
- 2017 Jan;49(1):e288.
- doi: 10.1038/emm.2016.135
Although chronic eosinophilic inflammation is a common feature in patients with asthma, some patients have neutrophil-dominant inflammation, which is known to be associated with severe asthma.Human mesenchymal stem cells (hMSCs)... -
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- Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway
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Kim YS, Kim JY, Cho R, Shin DM, Lee SW, Oh YM
- KMID: 2367530
- Exp Mol Med.
- 2017 Jan;49(1):e284.
- doi: 10.1038/emm.2016.127
Cell therapy using stem cells has produced therapeutic benefits in animal models of COPD. Secretory mediators are proposed as one mechanism for stem cell effects because very few stem cells... -
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- Gene-metabolite network analysis in different nonalcoholic fatty liver disease phenotypes
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Liu XL, Ming YN, Zhang JY, Chen XY, Zeng MD, Mao YM
- KMID: 2367529
- Exp Mol Med.
- 2017 Jan;49(1):e283.
- doi: 10.1038/emm.2016.123
We sought to identify common key regulators and build a gene-metabolite network in different nonalcoholic fatty liver disease (NAFLD) phenotypes. We used a high-fat diet (HFD), a methionine-choline-deficient diet (MCDD)... -
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