- Dynamic cross talk between metabolic organs in obesity and metabolic diseases
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Kim JB
- KMID: 2361501
- Exp Mol Med.
- 2016 Mar;48(3):e214.
- doi: 10.1038/emm.2015.119
No abstract available. -
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- Heterogeneity of white adipose tissue: molecular basis and clinical implications
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Kwok KH, Lam KS, Xu A
- KMID: 2361502
- Exp Mol Med.
- 2016 Mar;48(3):e215.
- doi: 10.1038/emm.2016.5
Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among different anatomical depots stems from their intrinsic differences in cellular and physiological properties, including developmental origin, adipogenic and proliferative... -
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- Pancreatic regulation of glucose homeostasis
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Röder PV, Wu B, Liu Y, Han W
- KMID: 2361506
- Exp Mol Med.
- 2016 Mar;48(3):e219.
- doi: 10.1038/emm.2016.6
In order to ensure normal body function, the human body is dependent on a tight control of its blood glucose levels. This is accomplished by a highly sophisticated network of... -
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- Recent progress in genetic and epigenetic research on type 2 diabetes
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Kwak SH, Park KS
- KMID: 2361507
- Exp Mol Med.
- 2016 Mar;48(3):e220.
- doi: 10.1038/emm.2016.7
Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. During the past decade, progress in genetic association studies has enabled the identification of... -
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- Regulation of glucose metabolism from a liver-centric perspective
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Han HS, Kang G, Kim JS, Choi BH, Koo SH
- KMID: 2361505
- Exp Mol Med.
- 2016 Mar;48(3):e218.
- doi: 10.1038/emm.2015.122
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual's health. The liver has a major role in the control of glucose... -
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- Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism
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Roh E, Song DK, Kim MS
- KMID: 2361503
- Exp Mol Med.
- 2016 Mar;48(3):e216.
- doi: 10.1038/emm.2016.4
Accumulated evidence from genetic animal models suggests that the brain, particularly the hypothalamus, has a key role in the homeostatic regulation of energy and glucose metabolism. The brain integrates multiple... -
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- Crosstalk between the heart and peripheral organs in heart failure
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Jahng JW, Song E, Sweeney G
- KMID: 2361504
- Exp Mol Med.
- 2016 Mar;48(3):e217.
- doi: 10.1038/emm.2016.20
Mediators from peripheral tissues can influence the development and progression of heart failure (HF). For example, in obesity, an altered profile of adipokines secreted from adipose tissue increases the incidence... -
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- Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation
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Woo SJ, Lee SM, Lim HS, Hah YS, Jung ID, Park YM, Kim HO, Cheon YH, Jeon MG, Jang KY, Kim KM, Park BH, Lee SI
- KMID: 2361508
- Exp Mol Med.
- 2016 Mar;48(3):e221.
- doi: 10.1038/emm.2015.124
The type III histone deacetylase silent information regulator 1 (SIRT1) is an enzyme that is critical for the modulation of immune and inflammatory responses. However, the data on its role... -
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- ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells
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Baik SH, Lee J, Lee YS, Jang JY, Kim CW
- KMID: 2361509
- Exp Mol Med.
- 2016 Mar;48(3):e222.
- doi: 10.1038/emm.2015.126
MicroRNAs (miRNAs) are negative regulators of gene expression, and miRNA deregulation is found in various tumors. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by short hairpin... -
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- Chronic stress accelerates ligature-induced periodontitis by suppressing glucocorticoid receptor-α signaling
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Lu H, Xu M, Wang F, Liu S, Gu J, Lin S, Zhao L
- KMID: 2361510
- Exp Mol Med.
- 2016 Mar;48(3):e223.
- doi: 10.1038/emm.2015.127
Periodontitis is a common chronic inflammatory disease. Recent studies have shown that chronic stress (CS) might modulate periodontal disease, but there are few models of CS-induced periodontitis, and the underlying... -
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- Estrogen-related receptor γ is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27
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Kim JH, Choi YK, Byun JK, Kim MK, Kang YN, Kim SH, Lee S, Jang BK, Park KG
- KMID: 2361500
- Exp Mol Med.
- 2016 Mar;48(3):e213.
- doi: 10.1038/emm.2015.115
Orphan nuclear receptor estrogen-related receptor γ (ERRγ) regulates cell growth and tumorigenesis in various cancers. However, the clinical relevance of ERRγ to hepatocellular carcinoma (HCC) remains unclear. Here we examined... -
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