- Engineering therapeutic antibodies targeting G-protein–coupled receptors
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Jo M, Jung ST
- KMID: 2361494
- Exp Mol Med.
- 2016 Feb;48(2):e207.
- doi: 10.1038/emm.2015.105
G-protein–coupled receptors (GPCRs) are one of the most attractive therapeutic target classes because of their critical roles in intracellular signaling and their clinical relevance to a variety of diseases, including... -
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- Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1
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Graham RM, Hernandez , Puerta N, De Angulo , Webster KA, Vanni S
- KMID: 2361497
- Exp Mol Med.
- 2016 Feb;48(2):e210.
- doi: 10.1038/emm.2015.116
Cancer cells typically display increased rates of aerobic glycolysis that are correlated with tumor aggressiveness and a poor prognosis. Targeting the glycolytic pathway has emerged as an attractive therapeutic route... -
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- Differentiation of human gingival mesenchymal stem cells into neuronal lineages in 3D bioconjugated injectable protein hydrogel construct for the management of neuronal disorder
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Rao SR, Subbarayan R, Dinesh MG, Arumugam G, Raja ST
- KMID: 2361496
- Exp Mol Med.
- 2016 Feb;48(2):e209.
- doi: 10.1038/emm.2015.113
The success of regeneration attempt is based on an ideal combination of stem cells, scaffolding and growth factors. Tissue constructs help to maintain stem cells in a required area for... -
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- Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis
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Park YJ, Yoo SA, Hwang D, Cho CS, Kim WU
- KMID: 2361498
- Exp Mol Med.
- 2016 Feb;48(2):e211.
- doi: 10.1038/emm.2015.120
To optimize treatment for rheumatoid arthritis (RA), it is ideal to monitor the disease activity on a daily basis because RA activity fluctuates over time. Urine can be collected routinely... -
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- 16S rRNA gene-based metagenomic analysis reveals differences in bacteria-derived extracellular vesicles in the urine of pregnant and non-pregnant women
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Yoo JY, Rho M, You YA, Kwon EJ, Kim MH, Kym S, Jee YK, Kim YK, Kim YJ
- KMID: 2361495
- Exp Mol Med.
- 2016 Feb;48(2):e208.
- doi: 10.1038/emm.2015.110
Recent evidence has indicated that bacteria-derived extracellular vesicles (EVs) are important for host–microbe communication. The aims of the present study were to evaluate whether bacteria-derived EVs are excreted via the... -
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- STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance
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Kim YJ, Kang Y, Park HY, Lee JR, Yu DY, Murata T, Gondo Y, Hwang JH, Kim YH, Lee CH, Rhee M, Han PL, Chung BH, Lee HJ, Kim KS
- KMID: 2361499
- Exp Mol Med.
- 2016 Feb;48(2):e212.
- doi: 10.1038/emm.2016.1
Striatal-enriched protein tyrosine phosphatase (STEP) is abundantly expressed in the striatum, which strongly expresses dopamine and opioid receptors and mediates the effects of many drugs of abuse. However, little is... -
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