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The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus

Jang YH, Min DS

  • KMID: 1506220
  • Exp Mol Med.
  • 2012 Oct;44(10):571-577.
Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. PLD is localized in most cellular organelles, where it is likely to play different...
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Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation

Kim HY, Cho HK, Yoo SK, Cheong J

  • KMID: 1506226
  • Exp Mol Med.
  • 2012 Oct;44(10):622-632.
Six transmembrane protein of prostate 2 (STAMP2) plays a key role in linking inflammatory and diet-derived signals to systemic metabolism. STAMP2 is induced by nutrients/feeding as well as by cytokines...
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Protective effects of transduced Tat-DJ-1 protein against oxidative stress and ischemic brain injury

Jeong HJ, Kim DW, Kim MJ, Woo SJ, Kim HR, Kim SM, Jo HS, Hwang HS, Kim DS, Cho SW, Won MH, Han KH, Park J, Eum WS, Choi SY

  • KMID: 1506222
  • Exp Mol Med.
  • 2012 Oct;44(10):586-593.
Reactive oxygen species (ROS) contribute to the development of a number of neuronal diseases including ischemia. DJ-1, also known to PARK7, plays an important role in transcriptional regulation, acting as...
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Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model

Moon MH, Jeong JK, Lee JH, Park YG, Lee YJ, Seol JW, Park SY

  • KMID: 1506224
  • Exp Mol Med.
  • 2012 Oct;44(10):603-614.
Higher levels of body fat are associated with an increased risk for development numerous adverse health conditions. FTY720 is an immune modulator and a synthetic analogue of sphingosine 1-phosphate (S1P),...
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Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice

Shin W, Berkowitz , Ryoo S

  • KMID: 1506223
  • Exp Mol Med.
  • 2012 Oct;44(10):594-602.
The incidence of cardiovascular disease is predicted to increase as the population ages. There is accumulating evidence that arginase upregulation is associated with impaired endothelial function. Here, we demonstrate that...
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Effects of echinomycin on endothelin-2 expression and ovulation in immature rats primed with gonadotropins

Wang Z, Zhang Z, Wu Y, Chen L, Luo Q, Zhang J, Chen J, Luo Z, Huang X, Cheng Y

  • KMID: 1506225
  • Exp Mol Med.
  • 2012 Oct;44(10):615-621.
Echinomycin is a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity, which plays a crucial role in ovarian ovulation in mammalians. The present study was designed to test the hypothesis that...
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Peroxisome proliferator-activated receptor delta agonist attenuates hepatic steatosis by anti-inflammatory mechanism

Lee MY, Choi R, Kim HM, Cho EJ, Kim BH, Choi YS, Naowaboot , Lee EY, Yang YC, Shin JY, Shin YG, Chung CH

  • KMID: 1506221
  • Exp Mol Med.
  • 2012 Oct;44(10):578-585.
Although peroxisome proliferator receptor (PPAR)-alpha and PPAR-gamma agonist have been developed as chemical tools to uncover biological roles for the PPARs such as lipid and carbohydrate metabolism, PPAR-delta has not...
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