- Intervention with costimulatory pathways as a therapeutic approach for graft-versus-host disease
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Kwon B
- KMID: 964662
- Exp Mol Med.
- 2010 Oct;42(10):675-683.
- doi: 10.3858/emm.2010.42.10.071
Graft-versus-host disease (GVHD) is mediated by mature donor T cells contained in the hematopoietic stem cell graft. During the development of GVHD, signaling through a variety of costimulatory receptors plays... -
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- Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression
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Lim EJ, Park DW, Lee JG, Lee CH, Bae YS, Hwang YC, Jeong JW, Chin BR, Baek SH
- KMID: 964666
- Exp Mol Med.
- 2010 Oct;42(10):712-720.
- doi: 10.3858/emm.2010.42.10.070
Synthetic oligodeoxynucleotides (ODN) with a CpG-motif are recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Stimulation of macrophages with TLR9 agonist prevented apoptosis induced by serum... -
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- Role of inducible nitric oxide synthase on the development of virus-associated asthma exacerbation which is dependent on Th1 and Th17 cell responses
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Shin TS, Lee BJ, Tae YM, Kim YS, Jeon SG, Gho YS, Choi DC, Kim YK
- KMID: 964667
- Exp Mol Med.
- 2010 Oct;42(10):721-730.
- doi: 10.3858/emm.2010.42.10.072
Asthma is characterized by airway inflammation induced by immune dysfunction to inhaled antigens. Although respiratory viral infections are the most common cause of asthma exacerbation, immunologic mechanisms underlying virus-associated asthma... -
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- Heat shock protein 90 regulates IkappaB kinase complex and NF-kappaB activation in angiotensin II-induced cardiac cell hypertrophy
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Lee KH, Jang Y, Chung JH
- KMID: 964665
- Exp Mol Med.
- 2010 Oct;42(10):703-711.
- doi: 10.3858/emm.2010.42.10.069
Heat shock protein 90 (HSP90), one of the most abundant proteins in the cardiac cells is essential for cell survival. Previous studies have shown that angiotensin II induces cardiac cell... -
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- Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits
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Chen B, Qin J, Wang H, Magdalou J, Chen L
- KMID: 964663
- Exp Mol Med.
- 2010 Oct;42(10):684-695.
- doi: 10.3858/emm.2010.42.10.067
The study investigated the effects of adenovirus-mediated gene transfection of basic fibroblast growth factor (bFGF), bFGF combined with interleukin-1 receptor antagonist protein (IL-Ra) and/or insulin-like growth factor-1 (IGF-1) both in... -
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- IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species
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Paek AR, Kim SH, Kim SS, Kim KT, You HJ
- KMID: 964664
- Exp Mol Med.
- 2010 Oct;42(10):696-702.
- doi: 10.3858/emm.2010.42.10.068
Expression of zinc-finger protein 143 (ZNF143), a human homolog of the Xenopus transcriptional activator protein Staf, is induced by various DNA-damaging agents including etoposide, doxorubicin, and gamma-irradiation. ZNF143 binds to... -
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