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Nerve growth factor(NGF) induces mRNA expression of the new transcription factor protein p48ZnF

Heese K, Nagai Y, Sawada T

  • KMID: 1380207
  • Exp Mol Med.
  • 2004 Apr;36(2):130-134.
Apoptosis, the cell's intrinsic death program, plays a crucial role in the regulation of tissue homeostasis, and abnormal inhibition of apoptosis is an indicator of cancer and autoimmune diseases, whereas...
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Application of DNA chip techniques for Yq microdeletion analysis in infertile males

Lee S, Joo HS, Lee SH, Park JE, Kim JM, Hwang JH, Cho KS, Hwang SY

  • KMID: 1380213
  • Exp Mol Med.
  • 2004 Apr;36(2):179-184.
Our aim was to apply DNA chip technology as a diagnostic tool in infertility research and clinics. Six loci, including a sex-determining region on the Y chromosome and five sequence-tagged...
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Trp-Lys-Tyr-Met-Val-Met stimulates phagocytosis via phospho-lipase D-dependent signaling in mouse dendritic cells

Lee HY, Kang HK, Jo EJ, Kim JI, Lee YN, Lee SH, Park YM, Ryu SH, Kwak JY, Bae YS

  • KMID: 1380208
  • Exp Mol Med.
  • 2004 Apr;36(2):135-144.
Dendritic cells (DCs) play a key role in activating the immune response against invading pathogens as well as dying cells or tumors. Although the immune response can be initiated by...
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Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase

Jang MJ, Lee MJ, Park HY, Bae YS, Min DS, Ryu SH, Kwak JY

  • KMID: 1380212
  • Exp Mol Med.
  • 2004 Apr;36(2):172-178.
Agents that elevate cellular cAMP are known to inhibit the activation of phospholipase D (PLD). We investigated whether PLD can be phosphorylated by cAMP-dependent protein kinase (PKA) and PKA-mediated phosphorylation...
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Proteomic analysis of human cerebral cortex in epileptic patients

Eun JP, Choi HY, Kwak YG

  • KMID: 1380214
  • Exp Mol Med.
  • 2004 Apr;36(2):185-191.
Epilepsy affects more than 0.5% of the world population and is known to be associated with a large genetic component eliciting an electrical hyperexcitability in the central nervous system. However,...
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Inactivation patterns of p16/INK4A in oral squamous cell carcinomas

Lee JK, Kim MJ, Hong SP, Hong SD

  • KMID: 1380211
  • Exp Mol Med.
  • 2004 Apr;36(2):165-171.
The p16/INK4A is one of the major target genes in carcinogenesis and its inactivation has frequently been reported in other types of tumors. The purpose of this study is to...
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Evidence that the fully assembled capsid of Leishmania RNA virus 1-4 possesses catalytically active endoribonuclease activity

Ro YT, Kim EJ, Lee HI, Saiz M, Jr RC, Patterson

  • KMID: 1380209
  • Exp Mol Med.
  • 2004 Apr;36(2):145-156.
In this study, Leishmania RNA virus 1-4 (LRV1-4) particles purified from host Leishmania guyanensis promastigotes were examined for capsid endoribonuclease. Temperature optimum for the endoribonulease activity was found to be...
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Association study of the angiotensin-converting enzyme (ACE) gene G2350A dimorphism with myocardial infarction

Iqbal MP, Mahmood S, Mehboobali N, Ishaq M, Fatima T, Parveen S, Frossard P

  • KMID: 1380204
  • Exp Mol Med.
  • 2004 Apr;36(2):110-115.
The angiotensin converting enzyme (ACE) is a strong candidate gene for myocardial infarction (MI). Insertion-deletion dimorphism in intron 16 of this gene has been inconclusively found to be associated with...
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Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells

Kim YS, Jhon DY, Lee KY

  • KMID: 1380210
  • Exp Mol Med.
  • 2004 Apr;36(2):157-164.
Selenium is a dietary essential trace nutrient with important biological roles. Selenocompounds were reported to induce apoptosis in many types of tumor cells. In this study, we investigated the signaling...
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Phospholipase D is involved in oxidative stress-induced migration of vascular smooth muscle cells via tyrosine phosphorylation and protein kinase C

Kim J, Min G, Bae YS, Min DS

  • KMID: 1380203
  • Exp Mol Med.
  • 2004 Apr;36(2):103-109.
Oxidative stress has been implicated in mediation of vascular disorders. In the presence of vanadate, H2O2 induced tyrosine phosphorylation of PLD1, protein kinase C-a (PKC-a), and other unidentified proteins in...
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Microsatellite instability and its correlation with clinicopathological features in a series of thyroid tumors prevalent in iodine deficient areas

Vaish M, Mishra A, Kaushal M, Mishra SK, Mittal B

  • KMID: 1380206
  • Exp Mol Med.
  • 2004 Apr;36(2):122-129.
Thyroid tumors display diverse spectrum of histopathological groups with geographic variation in its prevalence. Influence of iodine deficiency (a major causative factor) in its etiology, prevalence, or aggressiveness is debatable...
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Methylenetetrahydrofolate reductase polymorphism, diet, and breast cancer in Korean women

Lee SA, Kang D, Nishio H, Lee MJ, Kim DH, Han W, Yoo KY, Ahn SH, Choe KJ, Hirvonen A, Noh DY

  • KMID: 1380205
  • Exp Mol Med.
  • 2004 Apr;36(2):116-121.
To evaluate the interactive effect of methylenetetrahydrofolate reductase (MTHFR) genotype and dietary factors on the development of breast cancer, a hospital based case-control study was conducted in South Korean study...
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