- Mouse models for telomere and telomerase biology
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Cheong C, Hong KU, Lee HW
- KMID: 1094694
- Exp Mol Med.
- 2003 Jun;35(3):141-153.
Telomeres serve a critical role in maintenance of genomic stability in all eukaryotes, from yeast to human. The maintenance of telomeres is achieved by the telomerase complex, which is largely... -
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- Newly dentified members of the TNF recept or superfamily (mTNFRH1 and mTNFRH2) inhibit T-cell proliferation
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Kim J, La S, Kim BS, Kwon BS, Kwon B
- KMID: 1094695
- Exp Mol Med.
- 2003 Jun;35(3):154-159.
By searching an EST database, we identified two TNF receptor superfamily members (named mTNFRH1 and mTNFRH2). Amino acid sequences are highly conserved between the two receptors (78% identity). The chromosomal... -
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- Dexamethasone differentiates NG108-15 cells through cyclooxygenase1 induction
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Kim HS, Song M, Kim E, Ryu SH, Suh PG
- KMID: 1094702
- Exp Mol Med.
- 2003 Jun;35(3):203-210.
Cyclooxygenase (COX) is a key enzyme in the conversion of arachidonic acid into prostanoids which participate in various cellular functions including apoptosis, mitogenesis, inflammation, immune modulation and differentiation. Moreover, the... -
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- Role of sphingomyelin-MAPKs pathway in heat-induced apoptosis
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Chung HS, Park SR, Choi EK, Park HJ, Griffin RJ, Song CW, Park H
- KMID: 1094699
- Exp Mol Med.
- 2003 Jun;35(3):181-188.
The role of sphingomyelinase (SMase) activation and mitogen activated protein kinases (MAPKs) activation in cellular apoptosis was investigated during the hyperthermic treatment of HL-60 human leukemia cells. Treating the cells... -
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- Induction of nitric oxid esynthase(NOS) by soluble glucocorticoid induced tumor necrosis factor receptor(sGITR) is modulated by IFN-g in murine macrophage
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Shin HH, Lee HW, Choi HS
- KMID: 1094698
- Exp Mol Med.
- 2003 Jun;35(3):175-180.
Earlier study showed that glucocorticoid induced tumor necrosis factor receptor (GITR), a new TNFR family, activated murine macrophages to express inducible nitric oxide synthase (iNOS) and to generate nitric oxide... -
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- Angiotensin converting enzyme gene polym orphism in Korean patients with primary knee osteoarthritis
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Hong SJ, Yang HI, Yoo MC, In CS, Yim SV, Jin SY, Choe BK, Chung JH
- KMID: 1094700
- Exp Mol Med.
- 2003 Jun;35(3):189-195.
Angiotensin converting enzyme (ACE) plays an important role in the physiology of vasculature, blood pressure and inflammation. ACE gene, known to have insertion/deletion (I/D) polymorphism, has been widely investigated in... -
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- Expression of 3b-Hydroxysteroid dehydrogenase and P450 side chain cleavage enzyme in the human uterine endometrium
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Rhee HS, Oh SH, Ko BJ, Han DM, Jeon BH, Park H, Moon HB, Kim WS
- KMID: 1094696
- Exp Mol Med.
- 2003 Jun;35(3):160-166.
The enzyme complex 3b-hydroxysteroid dehydrogenase/delta(5)-delta(4)-isomerase (3beta-HSD) is involved in the biosynthesis of all classes of active steroids. The expression of 3beta-HSD in human uterine endometrium during the menstrual cycle and... -
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- Synergistic activation of p70S6 kinase associated with stem cell factor in MO7e cells
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Lee Y, Broxmeyer , Mantel C, Kwon HJ, Kim JW, Kim JS, Kwon D, Choe IS
- KMID: 1094704
- Exp Mol Med.
- 2003 Jun;35(3):222-226.
Stem cell factor (SCF) is an early-acting cytokine inducing proliferative synergy with other cytokines in hematopoietic cells. We earlier showed that p21 was synergistically induced in SCF synergy and the... -
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- High extracellular Ca2+ alone stimulates osteoclast formation but inhibits in the presence of other osteoclastogenic factors
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Shin MM, Kim YH, Kim SN, Kim GS, Baek JH
- KMID: 1094697
- Exp Mol Med.
- 2003 Jun;35(3):167-174.
High ambient Ca2+ at bone resorption sites have been implicated to play an important role in the regulation of bone remodeling. The present study was performed to clarify the mode... -
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- Phagocytosis of serum-and IgG-opsonized zymos an particles induces apoptosis through superoxide but not nitric oxide in macrophage J774A.1
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Kim JS, Kwon HY, Choi WH, Jeon CY, Kim JI, Kim J, Lee JY, Kim YS, Park JB
- KMID: 1094703
- Exp Mol Med.
- 2003 Jun;35(3):211-221.
Phagocytosis of serum- and IgG-opsonized zymosan (SOZ and IOZ, respectively) particles into J774A.1 macrophages induced apoptosis of the cells, accompanied by the expression of p21(WAF1), one of cyclin-dependent protein kinase... -
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- Association of transforming growth factor-b1 gene polymorphisms with a hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection
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Kim YJ, Lee HS, Im JP, Min BH, Kim HD, Jeong JB, Yoon JH, Kim CY, Kim MS, Kim JY, Jung JH, Kim LH, Park BL, Shin HD
- KMID: 1094701
- Exp Mol Med.
- 2003 Jun;35(3):196-202.
Transforming growth factor-b1 (TGF-beta 1) can act as both a tumor suppressor and a stimulator of tumor progression. We have examined the relationship between polymorphisms of the TGF-beta 1 gene... -
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