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Retrovirus-mediated transduction of a cytosine deaminase gene preserves the stemness of mesenchymal stem cells

Park JS, Chang DY, Kim JH, Jung JH, Park J, Kim SH, Lee YD, Kim SS, Suh-Kim H

  • KMID: 2154229
  • Exp Mol Med.
  • 2013 Feb;45(2):e10.
Human mesenchymal stem cells (MSCs) have emerged as attractive cellular vehicles to deliver therapeutic genes for ex-vivo therapy of diverse diseases; this is, in part, because they have the capability...
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Membrane transducing activity of recombinant Hoxc8 protein and its possible application as a gene delivery vector

Kim ES, Kang M, Park HW, Kim MH

In order to examine whether the Hoxc8 protein can deliver nucleic acid into mammalian cells, we designed several Hoxc8-derived recombinant proteins to be synthesized as glutathione S-transferase (GST) fused forms...
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T Cell-specific Immunosuppression Using Tautomycetin or PTD-conjugated Protein Drugs

Chae WJ, Choi JM, Yang JJ, Lee SK

No abstract available.
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Transduction of yeast cytosine deaminase mediated by HIV-1 Tat basic domain into tumor cells induces chemosensitivity to 5-fluorocytosine

Lee H, Ryu J, Kim KA, Lee KS, Lee JY, Park JB, Park J, Choi SY

  • KMID: 755664
  • Exp Mol Med.
  • 2004 Feb;36(1):43-51.
Enzyme/prodrug approach is one of the actively developing areas for cancer therapy. In an effort to develop more effective enzyme/prodrug systems, cell-permeable cytosine deaminase was produced by fusing yeast cytosine...
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