Korean J Dermatol.  1965 Aug;4(1):31-38.

Antifungal Effect of Griseofulvin to Various DErmatophytes

• Byun DK
• Suk CK
• Song JY
• Nam YJ
• Shin HC

Abstract

Although there have be n many reports concerning the antifungal effects with varinus dermatophytes, there has bean no such report in Korea, Authors investigated to know the characteristics of main pathogenic species of clermatophytes to griseofulvin in Korea, particuIary the T, ferrugineum to which no any griseofulvia sensitivity test has been made in literature, GriseofuIvin sensitivity test in vitro and elementary changes of the dermatophytes on the hanging drop culture were observed on total 81 strains isolated from dermatophytosis, consisting of 6I strains of T ferrugineurn, 6 strains of T, rubrum, 2 strains of T, mentagrophytes, 2 strains of T gypseum, 4 strains of, M canis and 6 strains of E, floccosum, and the following results were obtained 1) T, ferrugineum and E floccosum were the most sensitive, T. rubrum and M, canis were moderate, and T, gypseum and T, mentagrophytes were least to griseofulvin 2) Griseofulvin inhibited the growing hyphae moderately at even the minimum concentration of 0.122mcg/m] 3) All examined fungal hyphae were inhibited to grow by griseofulvin and formed the powdery spores macroscopically, 4) Variations of the hyphae such as shortening, curling, swelling, degeneration, clumping, and septation were observed microscopically with arthrospvres and microconidia which was rather smaller than normal in size.

MeSH Terms

Arthrodermataceae*
Griseofulvin*
Hyphae
Korea
Spores
Tinea
Griseofulvin