Korean J Intern Med.
2004 Jun;19(2):132-133.
Nail Changes During Docetaxel Containing Combination Chemotherapy
- Affiliations
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- 1Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. insookwoo@catholic.ac.kr
Abstract
- Nail toxicity following systemic chemotherapy is common. Onychopathy during the period of neutropenia following chemotherapy may cause subungual abscesses and serious infection. Despite taxoid-related toxicity being increasingly reported since 2000, there are still phase II systemic chemotherapy studies using taxoid that have never mentioned nail changes. Recently, new criteria for the evaluation of nail toxicity have been suggested. The present report is the first of its kind, in Korea, to describe a case of docetaxel-associated onychopathy, which improved following a reduction in the docetaxel dose.
MeSH Terms
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Antimetabolites, Antineoplastic/administration & dosage
Antineoplastic Agents, Phytogenic/administration & dosage/adverse effects
Antineoplastic Combined Chemotherapy Protocols/*adverse effects
Deoxycytidine/administration & dosage/analogs & derivatives
Dose-Response Relationship, Drug
Female
Fluorouracil/analogs & derivatives
Humans
Lymphatic Diseases/drug therapy
Middle Aged
Nail Diseases/*chemically induced
Stomach Neoplasms/drug therapy
Taxoids/*administration & dosage/*adverse effects
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