Korean J Intern Med.  2003 Sep;18(3):187-190.

Quinupristin/Dalfopristin-induced Sweet's Syndrome

Affiliations
  • 1Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, Korea. maxymus72@hanmail.net

Abstract

Quinupristin/Dalfopristin is a new combination of streptogramin antibiotics designed specifically to treat clinically significant infections due to Vancomycin-resistant Enterococcus Faecium. Sweet's syndrome is characterized by painful skin plaques, which is associated with dermal neutrophilic infiltration, fever and peripheral blood leukocytosis. Drug-induced Sweet's syndrome has a temporal relationship between drug ingestion, clinical presentation and the temporally-related resolution of lesions following drug withdrawal or on treatment with systemic corticosteroids. A 63-year-old woman received Quinupristin/Dalfopristin for acute pyelonephritis developed fever, arthralgia, vomiting, and painful erythematous skin plaques. A skin biopsy showed neutrophilic dermatosis, and there was rapid resolution of the symptoms and cutaneous lesions after discontinuation of Quinupristin/Dalfopristin, consistent with drug-induced Sweet's syndrome. To date, there has been no reported case of Sweet's syndrome associated with the use of Quinupristin/Dalfopristin.

Keyword

Sweet's syndrome; Quinupristin/Dalfopristin (Streptogramins)

MeSH Terms

Anti-Bacterial Agents/administration & dosage/*adverse effects
Female
Human
Middle Aged
Skin/drug effects/pathology
Sweet's Syndrome/*chemically induced/pathology
Virginiamycin/administration & dosage/*adverse effects/*analogs & derivatives
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