Korean J Intern Med.  2003 Sep;18(3):181-186.

Effects of Gender and Menstrual Cycle on Colonic Transit Time in Healthy Subjects

• Jung HK
• Kim DY
• Moon IH

Abstract

BACKGROUND
Measuring colonic transit time (CTT) by the radio-opaque marker method is simple, widely available and important for the diagnosis of slow transit constipation. Moreover, the effects of gender and menstrual cycle on CTT remain controversial. Thus, in this study, we examined the effects of gender and menstrual cycle on CTT in healthy subjects. METHODS: We measured CTT in 42 healthy subjects (21M, 21F) by using a radio-opaque marker, Kolomark (TM). Two simple abdominal radiographs were taken on the 4th and 7th days. Average daily intake of dietary fiber and menstrual history were surveyed. RESULTS: The mean CTT of the 42 healthy subjects was 26.5 +/- 19.4 hours. The mean CTT was not significantly different between the male and female subjects (22.3 +/- 16.1 h vs. 30.1 +/- 21.4 h, p> 0.05). However, the mean CTT of 11 female subjects in the luteal phase was significantly longer than that of 10 female subjects in the follicular phase (40.9 +/- 19.0 h vs. 20.6 +/- 19.2 h, p< 0.05). Serum progesterone level, age, BMI, and the average daily intake of dietary fiber did not correlate with CTT. CONCLUSION: The effects of the menstrual cycle should be considered in interpreting CTT in young women.

Keyword

Colonic transit time; Gender; Menstrual cycle

MeSH Terms

Adult
Colon/*physiopathology/radiography
Comparative Study
Constipation/physiopathology/radiography
Contrast Media
Female
Gastrointestinal Transit/*physiology
Human
Male
Menstrual Cycle/*physiology
Middle Aged
Radiography, Abdominal
Sex Factors
Support, Non-U.S. Gov't