Ann Surg Treat Res.  2024 Feb;106(2):93-105. 10.4174/astr.2024.106.2.93.

Short-term and long-term oncologic outcomes of self-expandable metallic stent compared with tube decompression for obstructive colorectal cancer: a systematic review and meta-analysis

• Ha GW
• Lee MR

• KMID: 2552390
• DOI: http://doi.org/10.4174/astr.2024.106.2.93

Abstract

Purpose
Patients with obstructive colorectal cancer managed by emergency surgery show high morbidity, mortality, and stoma formation rates. Decompression modalities, including the self-expandable metallic stent (SEMS) and tube drainage (TD), have been used to improve surgical outcomes. However, there have been limited studies comparing the 2 modalities. We performed a meta-analysis on short- and long-term outcomes between SEMS and TD.
Methods
PubMed, EMBASE, Cochrane Library, and Google Scholar were searched. Data were pooled, and the overall effect size was calculated using random effect models. Outcome measures were perioperative short-term and 3-year survival outcomes.
Results
We included 20 nonrandomized studies that examined 2,047 patients in the meta-analysis. The meta-analysis showed SEMS had better short-term outcomes in clinical success rate, decompression-related complications, laparoscopic surgery rate, stoma formation rate, and postoperative complication rate with a relative risk (RR) of 0.36 (95% confidence interval [CI], 0.24–0.54; I² = 20%), 0.32 (95% CI, 0.20–0.50; I ² = 0%), 0.47 (95% CI, 0.34–0.66; I² = 87%), 0.34 (95% CI, 0.24–0.49; I² = 52%), and 0.70 (95% CI, 0.54–0.89, I² = 28%), respectively. However, there was no significant difference between the 2 groups in 3-year overall survival (RR, 0.99; 95% CI, 0.77–1.27; I² = 0%).
Conclusion
Although the long-term oncologic impact of SEMS is still unclear compared with TD, the results of this metaanalysis may suggest that SEMS insertion can be performed more successfully and safely and may have benefits for shortterm perioperative outcomes compared with TD. Further studies are warranted to provide more definitive survival results.

Keyword

Colorectal neoplasms; Decompression tube; Intestinal obstruction,; Stents; Survival

Figure

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  Fig. 1 PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram.

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  Fig. 2 Forest plot of data in patients with self-expandable metallic stent (SEMS) compared with tube drainage (TD). (A) Clinical success rate. (B) Decompression-related complication rate. (C) Time interval to surgery. (D) Laparoscopic surgery rate. (E) Stoma formation rate. (F) Postoperative complication rate. (G) Length of hospital stay. CI, confidence interval; df, degree of freedom; SD, standard deviation.

• 

  Fig. 3 Forest plot of data in patients with self-expandable metallic stent (SEMS) compared with tube drainage (TD). (A) Three-year overall survival. (B) Three-year relapse-free survival.

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