J Obes Metab Syndr.
2023 Dec;32(4):322-329. 10.7570/jomes23042.
An Overview of the Mechanism behind Excessive Volume of Pericardial Fat in Heart Failure
- Affiliations
-
- 1Division of Cardiology, Cardiovascular Arrhythmia Center, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea
- KMID: 2550379
- DOI: http://doi.org/10.7570/jomes23042
Abstract
- Heart failure (HF) is a clinical syndrome characterized by myocardial dysfunction leading to inefficient blood filling or ejection. Regardless of the etiology, various mechanisms, including adipokine hypersecretion, proinflammatory cytokines, stem cell proliferation, oxidative stress, hyperglycemic toxicity, and autonomic nervous system dysregulation in the pericardial fat (PCF), contribute to the development of HF. PCF has been directly associated with cardiovascular disease, and an increased PCF volume is associated with HF. The PCF acts as neuroendocrine tissue that is closely linked to myocardial function and acts as an energy reservoir. This review aims to summarize each mechanism associated with PCF in HF.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Acute Heart Failure after Relief of Massive Pericardial Effusion
- Pathophysiologic Mechanism of the Cardiac Failure in the Subacute Diffuse Myocarditis associated with Granulomatous Myocarditis
- Quantification of Large Pericardial Effusion by Two-Dimensional Echocardiography
- Two Cases of Primary HypoThyroidism Presenting with Pericardial Effusion
- Hypothyroidism With Acute Renal Failure and Heart Failure
