J Vet Sci.  2023 Nov;24(6):e75. 10.4142/jvs.23101.

Diagnostic assessment of twodimensional shear wave elastography in relation to dimethyl arginine levels in dogs with chronic kidney disease

• Cho H
• Yang S
• Suh G
• Choi J

• KMID: 2548983
• DOI: http://doi.org/10.4142/jvs.23101

Abstract

Background
In veterinary medicine, previous studies regarding the diagnostic performance of shear wave elastography (SWE) in chronic kidney disease (CKD) are not consistent with each other. Moreover, there has been no study evaluating the relationship between symmetric dimethyl arginine (SDMA) concentration and renal shear wave velocity (SWV) using twodimensional SWE (2D SWE) in dogs with CKD.
Objectives
This study aimed to evaluate the diagnostic capability of 2D SWE in dogs with CKD and to assess the relationship between renal SWV and SDMA concentration.
Methods
Dogs with healthy kidneys and dogs with CKD underwent 2D SWE and SDMA assay. Renal stiffness was estimated as renal SWV in m/s.
Results
SDMA concentration had a weak positive correlation with the left (r = 0.338, p = 0.022) and right renal SWV (r = 0.337, p = 0.044). Renal SWV was not significantly different between healthy kidney and CKD groups in the left (p = 0.085) and right (p = 0.171) kidneys.
Conclusions
2D SWE may could not distinguish between dogs with healthy kidney and dogs with early stage of CKD, but it would be useful for assessing the serial change of renal function in dogs.

Keyword

Biopsy; canine disease; chronic renal diseases; stiffness; 2D