Tissue Eng Regen Med.
2023 Jun;20(3):389-409. 10.1007/s13770-023-00525-0.
Immunomodulation for Tissue Repair and Regeneration
- Affiliations
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- 1School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Republic of Korea
- 2Interdisciplinary Program for Bioengineering, Seoul National University, Seoul 08826, Republic of Korea
- 3Institute of Chemical Processes, Institute of Engineering Research, BioMAX, Seoul National University, Seoul 08826, Republic of Korea
- KMID: 2542959
- DOI: http://doi.org/10.1007/s13770-023-00525-0
Abstract
- Various immune cells participate in repair and regeneration following tissue injury or damage, orchestrating tissue inflammation and regeneration processes. A deeper understanding of the immune system’s involvement in tissue repair and regeneration is critical for the development of successful reparatory and regenerative strategies. Here we review recent technologies that facilitate cell-based and biomaterial-based modulation of the immune systems for tissue repair and regeneration. First, we summarize the roles of various types of immune cells in tissue repair. Second, we review the principle, examples, and limitations of regulatory T (Treg) cell-based therapy, a representative cell-based immunotherapy. Finally, we discuss biomaterial-based immunotherapy strategies that aim to modulate immune cells using various biomaterials for tissue repair and regeneration.
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